Abstract
LARGE intravenous doses of griseofulvin in rats have been found to arrest mitosis in metaphase in certain organs, for example, bone marrow, seminal epithelium and intestinal epithelium. We postulated that since griseofulvin taken orally is soon found in the keratin layer of the skin, there might be an antimitotic effect with a delay in the production, and a reduction in the number, of tumours that would be produced by applications of methylcholanthrene to the epidermis of mice. A pilot experiment was performed which gave quite unexpected results.
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BARICH, L., NAKAI, T., SCHWARZ, J. et al. Tumour-promoting Effect of Excessively Large Doses of Oral Griseofulvin on Tumours induced in Mice by Methylcholanthrene. Nature 187, 335–336 (1960). https://doi.org/10.1038/187335b0
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DOI: https://doi.org/10.1038/187335b0
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