Abstract
EXTENSIVE studies1 in the past few years have shown that the ability to transform the steroid molecule is widespread among various micro-organisms, and the types of reaction are numerous. Among them, 11α-hydroxylation is a quite common reaction with fungi1,2. More recently, it was found that two strains of bacteria have introduced the hydroxy group in progesterone3 and Reichstein'4 compound S at the 11α-position. However, with Actinomycetes this 11α-hydroxylation has not been reported, while 11β-hydroxylation of compond S by Streptomyces radiae 5 has been shown.
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References
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SHIRASAKA, M., TSURUTA, M. 11αHydroxylation of Steroids by Streptomyces Species. Nature 185, 845–846 (1960). https://doi.org/10.1038/185845a0
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DOI: https://doi.org/10.1038/185845a0
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