Abstract
THE production of immunological tolerance, that is, specific inhibition of the immune response in adult life by contact with antigen at an early age, was first described by Billingham, Brent and Medawar1 and Hašek2. By this means, animals of different strains or breeds can be made to accept skin homografts from each other in adult life, provided they have been injected in the fœtal or early neonatal period with cells taken from their future skin donors.
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References
Billingham, R. E., Brent, L., and Medawar, P. B., Nature, 172, 603 (1953).
Hašek, M., Csl. Biol., 2, 25 (1953).
Woodruff, M. F. A., and Simpson, L. O., Brit. J. Exp. Path., 36, 494 (1955).
Billingham, R. E., and Brent, L., Transpl. Bull., 4, 67 (1957).
Billingham, R. E., Brent, L., and Medawar, P. B., Phil. Trans., B, 239, 357 (1956).
Stark, R. B., Brownlee, H., and Grunwald, R. P., Ann. N.Y. Acad. Sci., 73, 772 (1958).
Medawar, P. B., J. Anat., 78, 176 (1944).
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PORTER, K. Runt Disease and Tolerance in Rabbits. Nature 185, 789–790 (1960). https://doi.org/10.1038/185789a0
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DOI: https://doi.org/10.1038/185789a0
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