Abstract
ONLY rarely and depending on special conditions has actively acquired immunity been demonstrated for tumours indigenous to and tested within inbred strains of mice1–3 or rats4. For this reason doubts have been expressed as to whether ‘tumour immunity’ exists independent of isoantigenic differences. Experiments carried out in this laboratory and summarized in Table 1 have utilized inoculation into mice of inbred strains of tumours produced in F 1 hybrid mice derived from the corresponding parent strains. Mice of the parent strain in which the F 1 ‘hybrid tumour’ failed to grow were challenged with a tumour indigenous to and specific for their own strain.
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References
Foley, E. J., Proc. Soc. Exp. Biol. and Med., 80, 675 (1952).
Prehn, R. T., and Main, J. M., J. Nat. Cancer Inst., 18, 769 (1957).
Prince, J. E., Fardon, J. C., Nutini, L. G., and Sperti, G. S., Cancer Res., 17, 312 (1957).
Goldner, H., Bogden, A. E., and Aptekman, P. M., J. Immunol., 12, 520 (1959).
Klein, E., and Klein, G., Transplant. Bull., 3, 136 (1956).
Dunham, L. J., and Stewart, H. L., J. Nat. Cancer Inst., 13, 1299 (1953).
Davidsohn, I., and Stern, K., J. Immunol., 72, 216 (1954).
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STERN, K. A New Approach to Tumour Immunity. Nature 185, 787–788 (1960). https://doi.org/10.1038/185787a0
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DOI: https://doi.org/10.1038/185787a0
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