Abstract
PREVIOUSLY, we have presented evidence that as a result of the corpuscular blood trauma inherent to extracorporeal circulatory systems including the heart–lung machines, adenosine triphosphate and 5-hydroxytryptamine (serotonin) are released into plasma, the former being derived mainly from the hæmolysed red cells and the latter from the disintegrated platelets. Concurrently, the urinary excretion of 5-hydroxytryptamine was increased, while, rather unexpectedly, there was a reduction in the excretion of 5-hydroxyindoleacetic acid, the main excretory product of hydroxytryptamine1. Since intravasal hæmolysis caused in any way may evoke an acute tubular (‘lower nephron’) nephrosis2,3 and since, on the other hand, 5-hydroxyindoleacetic acid has been reported to be excreted also by active tubular secretion4, we have studied the renal changes in a part of the animals, in which the above blood and urinary changes were found.
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References
Sarajas, H. S. S., Kristoffersson, R., and Frick, M. H., Nature, 184, 1127 (1959); Amer. J. Physiol., 197, 1195 (1959).
Burch, G. E., and Ray, C. T., Ann. Int. Med., 31, 750 (1959).
Ogilvie, R. F., “Pathological Histology” (E. and S. Livingstone, Ltd., Edinburgh, 1951).
Despopoulos, A., and Weissbach, H., Amer. J. Physiol., 189, 548 (1957).
Blaschko, H., and Hellmann, K., J. Physiol., 122, 419 (1953).
Schmutzer, K. J., Marable, S. A., Ruschke, E., Maloney, J. V., and Longmire, W. P., Langenbecks Arch. klin. Chir., 290, 64 (1958).
Daly, I. De Burgh, Eggleton, P., Hebb, Catherine, Linzell, J. L., and Trowell, O. A., Quart. J. Exp. Physiol., 39, 29 (1954).
Brull, L., and Louis-Bar, D., Arch. Internat. Physiol. et Biochem., 65, 470 (1957).
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SARAJAS, H., SAURE, L. Renal Affection resulting from Blood Trauma in Extracorporeal Circuits. Nature 185, 768–770 (1960). https://doi.org/10.1038/185768b0
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DOI: https://doi.org/10.1038/185768b0
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