Lack of Correlation between Synthesis of Nucleic Acids and Proteins in Denervated Muscle

Abstract

AFTER direct electrical stimulation of a muscle, non-collagen protein decreases and is later re-synthesized¹. The rate of resynthesis is considerable, 1.9 mgm. of non-collagen protein/gm. of muscle tissue being resynthesized during 1 hr. The course of this accentuation of proteosynthesis was followed in the normal and denervated muscle. Fig. 1 shows that the decrease of proteins after stimulation of the muscle is the same in normal and denervated muscle and is accompanied by a decrease of ribonucleic acid, amounting to 15 per cent in the normal and 50 per cent in the denervated muscle. Such a decrease of ribonucleic acid and also an increase in proteolysis has been described after stimulation of nerve and brain tissue².