Abstract
THE purpose of the present study was to determine whether steroids, when conjugated by stable covalent bonds to proteins, could act as haptenic groups in inducing steroid-specific antibodies. A detailed account of the method used for synthesizing œstrone–protein conjugates has been published elsewhere1. In brief, œstrone was converted to œstrone-17-isocyanate and the latter was allowed to react with human and bovine serum albumin to yield the corresponding œstrone-17-carbamide-protein conjugates.
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References
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GOODFRIEND, L., SEHON, A. Antigenicity of Œstrone–Protein Conjugates. Nature 185, 764–766 (1960). https://doi.org/10.1038/185764a0
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DOI: https://doi.org/10.1038/185764a0
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