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Labelling of Deoxyribose with Carbon-14 in Relation to Incorporation of Phosphorus-32 into the Nucleotides of Deoxyribonucleic Acid of Rat Thymus Cells

Abstract

IT has previously been shown1,2 that when rat thymus cells are incubated in the presence of glucose labelled with carbon-14, the isotope is incorporated to a different extent in the ribose moieties of the four individual types of nucleotide derived from ribonucleic acid. The ribose attached to the pyrimidine bases has a specific activity lower than that of the purine-bound ribose. The present report deals with experiments on the sugar component of deoxyribonucleic acid, and also with a comparison of carbon-14-labelling of deoxyribose and incorporation of phosphorus-32 into the nucleotides of deoxyribonucleic acid.

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ITZHAKI, S. Labelling of Deoxyribose with Carbon-14 in Relation to Incorporation of Phosphorus-32 into the Nucleotides of Deoxyribonucleic Acid of Rat Thymus Cells. Nature 185, 614–615 (1960). https://doi.org/10.1038/185614a0

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