Abstract
THE rate of reaction between a chelating agent and a hydrolysable polyvalent metal ion such as thorium (IV) is dependent on the degree of polymerization of the metal ion. It would be anticipated, therefore, that the degree to which a chelating agent might enhance the excretion rate of certain radioelements from the body would be variable even though factors such as dose and route of administration were kept constant. Accordingly, we investigated the effect of a strong chelating agent on the excretion of thorium-234 which was injected intravenously into rats in two different forms—a monomeric, diffusible form and a polymeric or colloidal form. The chelating agent used was diethylenetriaminepentaacetic acid, which forms an exceptionally strong chelate with thorium1 (the 1 : 1 chelate has a log K = >27).
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References
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Schubert, J., and Lindenbaum, A. (submitted for publication).
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SCHUBERT, J., FRIED, J. Chelating Agents in the Treatment of Poisoning by Polymerizable Radioelements. Nature 185, 551–552 (1960). https://doi.org/10.1038/185551a0
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DOI: https://doi.org/10.1038/185551a0
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