Abstract
AMONG the substances recently introduced in the therapy of mental depression which stimulate the central nervous system, iproniazide (1-isonicotinoyl-2-isopropyl-hydrazine) has been the drug longest under investigation1. Its stimulating properties have been discovered by studying this drug as a tuberculostatic agent; and during this work toxic psychoses have been observed as side-effects.
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References
See J. Amer. Med. Assoc., 168, 286 (1958).
See conclusion, Logemann, W., and Miori, G. P., Arzneimittelforschung, 5, 213 (1955).
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This acid has recently been obtained by another method; see Biel, J. H., Drukker, A. E., Mitschell, Th. F., Sprengeler, E. P., Nuhfer, P. A., Conway, A. C., and Horita, H., J. Amer. Chem. Soc., 81, 2805 (1959).
For futher details see Manzini, B., Goldwurm, G. F., and Canal, N., Boll. Soc. Ital. Biol. speriment., 34, 1407 (1958). Canal, N., Maffei-Faccioli, A., and Manzini, B., ibid., 34, 1525 (1958); and Atti Soc. Lomb. Scienze Med. e Biol. (in the press).
Bersin, Th., in “Ion Exchangers in Organic and Biochemistry”, 498 (Intersci. Publ., New York, 1957).
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LOGEMANN, W., LAURIA, F. & ARTINI, D. Methanesulphonic Acid Derivatives of Central Stimulant Drugs. Nature 185, 532–533 (1960). https://doi.org/10.1038/185532a0
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DOI: https://doi.org/10.1038/185532a0
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