Abstract
THE fate of antibodies in normal human γ-globulin preparations during storage was studied by Gerlough1, who succeeded in achieving surprising results: the half-time of diphtheria antitoxin in the preparation was 23 years—under strict storage conditions even 40–69 years. Tiselius electrophoresis and ultra-centrifugation did not reveal cleavage or denaturation of the protein molecule.
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References
Gerlough, T. D., Twelfth Conference on Blood Cells and Plasma Proteins, Albany, N.Y. (November 1957).
Ouchterlony, O., Acta Pathol. microbiol. Scand., 25, 186 (1948); 32, 231 (1953).
Lever, F. W., Gurd, F. R. K., Uroma, E., Brown, R. K., Barnes, B. A., Schmid, K., and Schultz, E. L., J. Clin. Invest., 30, 99 (1951).
Morrison, W. L., and Neurath, H., J. Biol. Chem., 200, 39 (1953).
Porter, R. R., Nature, 182, 670 (1958).
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ŠKVAŘIL, F. Changes in Outdated Human γ-Globulin Preparations. Nature 185, 475–476 (1960). https://doi.org/10.1038/185475a0
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DOI: https://doi.org/10.1038/185475a0
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