Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Evidence for Protein Turnover in an Embryonic System

Abstract

IN a previous communication we have compared the relative efficiency of various proteins, peptides and free amino-acids as precursors of chick embryonic proteins1. From these studies we concluded that during the early stages of development the preferred precursor was yolk protein (rather than peptides or amino-acids) and that the pathway of synthesis of chick embryonic protein probably proceeded via a stage involving amino-acid derivatives (possibly amino acyl adenylates2 or, more likely, amino-acids linked to the terminal adenosine residues of polyribonucleotides3–6).

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Walter, H., and Mahler, H. R., J. Biol. Chem., 230, 241 (1958).

    CAS  PubMed  Google Scholar 

  2. Hoagland, M. D., Keller, E. B., and Zamecnik, P. C., J. Biol. Chem., 218, 345 (1956).

    CAS  PubMed  Google Scholar 

  3. Schweet, R. S., Bovard, F. C., Allen, E., and Glassman, F., Proc. U.S. Nat. Acad. Sci., 44, 173 (1958).

    Article  ADS  CAS  Google Scholar 

  4. Zachau, H. G., Acs, G., and Lipmann, F., ibid., 44, 885 (1958).

  5. Preiss, J., Berg, P., Ofengand, E. J., and Bergman, F. H., ibid., 45, 319 (1959).

  6. Hecht, L. I., Stephenson, M. C., and Zamecnik, P. C., ibid., 45, 505 (1959).

  7. Wood, J. L., and Perkinson, J. D., J. Amer. Chem. Soc., 74, 2444 (1952).

    Article  CAS  Google Scholar 

  8. Williams, R. B., and Dawson, R. M. C., Biochem. J., 52, 314 (1952).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Walter, H., Haurowitz, F., Fleiseher, S., Lietze, A., Cheng, H. F., Turner, J. E., and Friedberg, W., J. Biol. Chem., 224, 107 (1957).

    CAS  PubMed  Google Scholar 

  10. Walter, H., Allmann, D. W., and Mahler, H. R., Science, 124, 1251 (1956).

    Article  ADS  CAS  PubMed  Google Scholar 

  11. Spiegelman, S., in “Enzymes, Units of Biological Structure and Function”, ed. by Gaebler, O. H. (Academic Press, 1956).

    Google Scholar 

  12. Hogness, D. S., Cohn, M., and Monod, J., Biochim. Biophys. Acta, 16, 99 (1955).

    Article  CAS  PubMed  Google Scholar 

  13. Reviewed by Pollock, M. R., in “The Enzymes”, 2nd ed. (ed. by P. D. Boyer, H. A. Lardy, and K. Myrback) (Academic Press, New York, 1959).

  14. Romanoff, A. L., Ann. N.Y. Acad. Sci., 55, 288 (1955).

    Article  ADS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

WALTER, H., MAHLER, H. Evidence for Protein Turnover in an Embryonic System. Nature 185, 398–399 (1960). https://doi.org/10.1038/185398a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/185398a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing