Abstract
MONOAMINOXIDASE has been linked with vascular and mental activity1,3. Among the most ancient modifiers of mental status are the alcohols, which have been shown4 to modify monoaminoxidase in vitro. During our endeavours to develop this correlation further, we encountered a puzzling periodic activation and inhibition of this enzyme. For five years, the postulation of a tenable explanation has escaped not only our own interpretative capacities, but also those of the recognized specialists whom we have consulted. The recent studies of aliphatic compounds which have accompanied the discovery of irin5 have provided our experiments with added interest : it now seems possible that enzymatic modification by aliphatic compounds might constitute a regulatory mechanism in the contraction of smooth muscle.
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References
Bogdanski, D. F., and Udenfriend, S., J. Pharmacol. and Exp. Therap., 116, 7 (1956).
Broadie, B. B., Pletscher, A., and Shore, P. A., J. Pharmacol. and Exp. Therap., 116, 9 (1956).
Broadie, B. B., Tourich, B. G., Kuntzman, R., and Shore, P. A., J. Pharmacol. and Exp. Therap., 119, 461 (1957).
Heim, F., Arch. Exp. Path. Pharmakol., 210, 16 (1950).
Ambach, N., J. Physiol., 146, 255 (1959).
Cotzias, G. C., and Greenough, J. J., Arch. Biochem. Biophys., 75, 15 (1958).
Cotzias, G. C., and Greenough, J. J., Nature, 183, 1732 (1959).
Cotzias, G. C., and Dole, V. P., J. Biol. Chem., 190, 665 (1951).
Cotzias, G. C., and Dole, V. P., Proc. Soc. Exp. Biol. and Med., 78, 157 (1951).
Cotzias, G. C., Serlin, I., and Greenough, J. J., Science, 120, 114 (1954).
Product of Antara Chemicals, a division of General Aniline and Film Corp.
Blaschko, H., Pharmacol. Rev., 4, 415 (1952).
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COTZIAS, G., GREENOUGH, J. Dependence of Periodic Activation and Inhibition of Monoaminoxidase by Aliphatic Compounds upon Chain-length. Nature 185, 384–385 (1960). https://doi.org/10.1038/185384a0
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DOI: https://doi.org/10.1038/185384a0
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