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Synthetic Polypeptide Derivatives with Anti-Bacterial Activities

Abstract

A NUMBER of polypeptides composed of various basic amino-acids have been prepared by Katchalski et al., and it had also been stated that agglutination of Grain-positive and Gram-negative bacteria was caused by these polypeptides, and bacteriostatic or bactericidal activity was observed depending on their concentration1. Stahmann and his co-workers2 have reported that the multiplication of some viruses was restrained by poly-L-lysine.

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References

  1. Katchalski, E., Bichowsky-Slomnitzki, L., and Volcani, B. E., Biochem. J., 55, 671 (1953).

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  2. Burger, W. C., and Stahmann, M. A., Arch. Biochem. Biophys., 39, 27 (1952).

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  3. Kovács, K., Dénes, G., Kótai, A., and Polgár, L., Naturwiss., 42, 628 (1955).

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KOVÁCS, K., KÓTAI, A. & SZABÓ, I. Synthetic Polypeptide Derivatives with Anti-Bacterial Activities. Nature 185, 266–267 (1960). https://doi.org/10.1038/185266a0

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  • DOI: https://doi.org/10.1038/185266a0

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