Abstract
WE have examined the distribution in mice of the metabolic products of two œstrogens by an autoradiographic method which allows histological localization. It is of interest to use a ‘physiological’ dose, which Dodds1 estimates to be close to 1 µgm. hexœstrol in the rat. Glascock and Hoekstra2, using tritium-labelled hexœstrol in the goat and the sheep, found that the maximum quantity of the injected product which could be recovered did not at any time exceed 0.2 per cent in the uterus or 0.05 per cent in the vagina.
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References
Dodds, E. C., Folley, S. J., Glascock, R. F., and Lawson, W., Biochem. J., 68, 161 (1958).
Glascock, R. F., and Hoekstra, W. G., Biochem. J., 72, 673 (1959).
Ficq, A., Arch. Biol., 66, 509 (1955).
Budy, A. M., Arch. intern. Pharmacodynamie, 103, 435 (1955).
Rengler, I., Proc. Soc. Exp. Biol. Med., 95, 506 (1957).
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PAEPE, J. An Autoradiographic Study of the Distribution in Mice of Œstrogens labelled with Carbon-14 and Tritium. Nature 185, 264–265 (1960). https://doi.org/10.1038/185264a0
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DOI: https://doi.org/10.1038/185264a0
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