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The Nuclear Membrane as a Barrier to the Free Diffusion of Proteins

Abstract

A RECENT investigation of the osmotic properties of the nucleus in intact frog oocytes has indicated that the nuclear membrane of these cells is not freely permeable to large molecules (mol. wt. 40,000 or greater)1. The present investigation was carried out in order to determine whether or not similar results could be obtained for oocytes of an unrelated species.

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References

  1. Harding, C. V., and Feldherr, C. M., J. Gen. Physiol., 42, 1155 (1959).

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  2. Stern, H., and Mirsky, A. E., J. Gen. Physiol., 37, 177 (1953).

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FELDHERR, C., FELDHERR, A. The Nuclear Membrane as a Barrier to the Free Diffusion of Proteins. Nature 185, 250–251 (1960). https://doi.org/10.1038/185250a0

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