Abstract
WE have reported that the isolated perfused rat liver from a fasted animal produces urea in linear fashion1, at the expense of both liver and plasma proteins. Urea production occurs, and the blood amino-acid level is maintained in the absence of added extraneous amino-acids. When a free amino-acid supplement is added, urea production is greatly enhanced. The addition of glucose or fructose supplements is associated with a nitrogen-sparing effect manifest as a diminished production of urea. This nitrogen-sparing effect is seen in either the presence or absence of added amino-acids.
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MILLER, L. Glucagon: a Protein Catabolic Hormone in the Isolated Perfused Rat Liver. Nature 185, 248 (1960). https://doi.org/10.1038/185248a0
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DOI: https://doi.org/10.1038/185248a0
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