Abstract
RATS fed on Himsworth's1 necrogenic diet have livers that are histologically undamaged, except for mild fatty infiltration, until an episode of acute massive necrosis occurs. Schwarz et al. 2 reported that liver slices from animals fed a necrogenic diet showed a metabolic abnormality at times when the livers were still normal hisbologically. The abnormality consists of an inability of these slices to maintain oxygen uptake for more than about 30 min. when incubated in Ringer solution at 38° with oxygen.
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References
Lindan, O., and Himsworth, H. P., Brit. J. Exp. Path., 31, 651 (1950).
Chernick, S. S., Moe, J. G., Rodnan, G. P., and Schwarz, K., J. Biol. Chem., 217, 829 (1955).
Cohen, P. P., in “Manometric Techniques and Tissue Metabolism”, ed. Umbreit, 119 (Burgess, Minneapolis, 1949).
Gallagher, C. H., Gupta, D. N., Judah, J. D., and Rees, K. R., J. Path. Bact., 72, 193 (1956).
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McLEAN, A. ‘Phenergan’ and Versene in Dietary Liver Necrosis. Nature 185, 191–192 (1960). https://doi.org/10.1038/185191a0
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DOI: https://doi.org/10.1038/185191a0
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