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Anti-tumour Activities of Copper Chelates

Nature volume 185, pages 190–191 (1960)Cite this article

Abstract

CHELATING agents have been shown to interfere with the utilization of metals by micro-organisms, robbing cells of their necessary metals1. Retardation of growth of a tumour (sarcoma 37) by the administration of two chelating agents, dipyridyl and O-phenanthroline, was observed by Leiter et al. 2. Now, α-ketoglutaric acid oxime has been found to form its copper, iron, or nickel chelate at the physiological pH, and its antitumour activity in vitro was observed by the stained cell count method3.

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References

  1. Forsfall, J. G., “Principles of Fungicidal Action” (Chronica Botanica Co. Waltham, Mass. 1956).

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  2. Leiter, J., et al., J. Nat. Cancer Inst., 14, 365 (1953).

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  3. Kikuchi, K., and Matsuzawa, M., J. Antibiotics (Japan), Ser. B, 8, 170 (1955). Kamata, H., et al., ibid., Ser. B, 11, 1 (1958).

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Author notes

  1. KAZUHIKO TAKAMIYA

    Present address: Yoshimura Oil Chem. Co., Ltd., Toyonaka City, Osaka, Japan

Authors and Affiliations

  1. Department of Agricultural Chemistry, Faculty of Agriculture, University of Tokyo, Tokyo

    KAZUHIKO TAKAMIYA

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  1. KAZUHIKO TAKAMIYA
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TAKAMIYA, K. Anti-tumour Activities of Copper Chelates. Nature 185, 190–191 (1960). https://doi.org/10.1038/185190a0

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