Abstract
IN order to correct the deficient plasma thromboplastin generation in hæmophilia, extraordinary amounts of antihæmophilic globulin are required1. This has been attributed to the inhibitory action of Bridge anticoagulant2. The fact that the latter is characteristically absent in serum3 prompted further investigations on the changes in the concentration of this inhibitor during the process of coagulation. The results (Table 1) revealed that full activity was maintained until the clotting of fibrinogen, following which event the anticoagulant rapidly became inert. Theoretically this meant that the removal of Bridge anticoagulant may be accomplished by one of three processes; adsorption on fibrin, destruction by thrombin or inactivation by a compound formed by thrombin-fibrinogen interaction.
Similar content being viewed by others
Article PDF
References
Macfarlane, R. G., Mallam, P. C., Witts, L. J., Bidwell, E., Biggs, R., Fraenkel, G. J., Honey, G. E., and Taylor, K. B., Lancet, ii, 251 (1957).
Nour-Eldin, F., and Wilkinson, J. F., Brit. J. Hæmat., 4, 292 (1958).
Nour-Eldin, F., and Wilkinson, J. F., Nature, 180, 990 (1957). Brit. J. Hæmat., 4, 38 (1958).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
NOUR-ELDIN, F. Neutralization of Bridge Blood Anticoagulant. Nature 184, 1419 (1959). https://doi.org/10.1038/1841419a0
Issue Date:
DOI: https://doi.org/10.1038/1841419a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.