Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Possible Enzymic Mechanism for the Development of Resistance against Fluorouracil in Ascites Tumours

Nature volume 183, pages 939–941 (1959)Cite this article

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Heidelberger, C., Chaudhuri, N. K., Danneberg, P., Mooren, D., Griesbach, L., Duschinsky, R., Schnitzer, R. J., Pleven, E., and Scheiner, J., Nature, 179, 663 (1957).

    Article  CAS  ADS  PubMed  Google Scholar 

  2. Heidelberger, C., Griesbach, L., Montag, B. J., Mooren, D., Cruz, O., Schnitzer, R. J., and Grunberg, E., Cancer Res., 18, 305 (1958).

    CAS  PubMed  Google Scholar 

  3. Chaudhuri, N. K., Montag, B. J., and Heidelberger, C., Cancer Res., 18, 318, (1958).

    CAS  PubMed  Google Scholar 

  4. Danneberg, P. B., Montag, B. J., Heidelberger, C., Cancer Res., 18, 329 (1958).

    CAS  PubMed  Google Scholar 

  5. Bosch, L., Harbers, E., and Heidelberger, C., Cancer Res., 18, 335 (1958).

    CAS  PubMed  Google Scholar 

  6. Eidinoff, M. L., Knoll, J. E., and Klein, D., Arch. Biochem. and Biophys., 71, 274 (1957).

    Article  CAS  Google Scholar 

  7. Cohen, S. S., Flaks, J. G., Barner, H. D., Loeb, M. R., and Lichtstein, J., Proc. U.S. Nat. Acad. Sci., 44, 1004 (1958).

    Article  CAS  ADS  Google Scholar 

  8. Heidelberger, C., Griesbach, L., Cruz, O., Schnitzer, R. J., and Grunberg, E., Proc. Soc. Exp. Biol. Med., 97, 470 (1958).

    Article  CAS  PubMed  Google Scholar 

  9. Sköld, O., Biochim. Biophys. Acta, 29, 651 (1958).

    Article  PubMed  Google Scholar 

  10. Lagerkvist, U., Reichard, P., Carlsson, B., and Grabosz, J., Cancer Res., 15, 164 (1955).

    CAS  PubMed  Google Scholar 

  11. Reichard, P., and Sköld, O., Acta Chem. Scand., 11, 17 (1957).

    Article  CAS  Google Scholar 

  12. Reichard, P., and Sköld, O., Biochim. Biophys. Acta., 28, 376 (1958).

    Article  CAS  PubMed  Google Scholar 

  13. Sköld, O. (unpublished work).

  14. Pontis, H., and Reichard, P. (unpublished work).

  15. Law, L. W., Cancer Res., 16, 698 (1956).

    CAS  PubMed  Google Scholar 

  16. Handschumacher, R. E., Biochim. Biophys. Acta, 23, 428 (1957).

    Article  CAS  PubMed  Google Scholar 

  17. Brockman, R. W., Hutchison, D. J., and Skipper, H. E., Fed. Proc., 17, 193 (1958).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry I, Karolinska Institutet, Stockholm, Sweden

    PETER REICHARD & OLA SKÖLD

  2. Department of Tumour Biology, Karolinska Institutet, Stockholm, Sweden

    GEORGE KLEIN

Authors
  1. PETER REICHARD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. OLA SKÖLD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. GEORGE KLEIN
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

REICHARD, P., SKÖLD, O. & KLEIN, G. Possible Enzymic Mechanism for the Development of Resistance against Fluorouracil in Ascites Tumours. Nature 183, 939–941 (1959). https://doi.org/10.1038/183939a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/183939a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing