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The γ-Aminobutyric Acid and Glutamic Acid Content of Brains of Rats treated with Toxopyrimidine

Nature volume 183, pages 608–609 (1959)Cite this article

Abstract

IN 1939, Abderhalden1 found that the administration of the pyrimidinic moiety of the thiamine molecule (2-methyl, 4-amino, 5-oxymethylpyrimidine; toxopyrimidine) to rats reared on suitable diet caused convulsions and death in a few hours. Afterwards, Makino et al. 2,3 showed that the convulsive action of the toxopyrimidine could be overcome by administering pyridoxamine, and Makino and Koike4,5 gave enzymatic evidence of the competitive antagonism between vitamin B6 and toxopyrimidine showing the in vitro inhibition of tyrosine-decarboxylase by toxopyrimidine phosphate.

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References

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Authors and Affiliations

  1. Institute of Human Physiology, University of Pavia,

    G. RINDI & G. FERRARI

Authors
  1. G. RINDI
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  2. G. FERRARI
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RINDI, G., FERRARI, G. The γ-Aminobutyric Acid and Glutamic Acid Content of Brains of Rats treated with Toxopyrimidine. Nature 183, 608–609 (1959). https://doi.org/10.1038/183608a0

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