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Complement Fixation with Tissue Culture and Liver Antigens of Mouse Hepatitis

Nature volume 183, pages 1690–1691 (1959)Cite this article

Abstract

HOST-SPECIFIC viruses associated with hepatitis of duck1, dog2, mouse3–6, and man7 have been described. The agents of duck8, dog9 and mouse10,11 hepatitis have been propagated in tissue culture. Complement-fixing antigens have been prepared from infected livers of mouse12 and dog13. However, studies on propagation and serology of human hepatitis viruses have as yet yielded equivocal results14. By means of virus-neutralization tests in mice, Gledhill et al. 15 noted an antigenic relationship among strains of murine hepatitis virus. They stated that JHM, Nelson, and MHV strains probably form a related group of viruses.

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References

  1. Levine, P. P., and Fabricant, J., Cornell Vet., 40, 71 (1950). Asplin, F. D., Vet. Rec., 68, 412 (1956). Hanson, L. E., and Alberts, J. O., J. Amer. Vet. Med. Assoc., 128, 37 (1956).

    Google Scholar 

  2. Rubarth, S., Acta Pathol. Microbiol. Scand., Supp., 69, 1 (1947).

    Google Scholar 

  3. Gledhill, A. W., and Andrewes, C. H., Brit. J. Exp. Path., 32, 559 (1951).

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Buescher, E. L., Ann. Historical Rep. of 406 Gen. Med. Lab., U.S. Army (1952) (cited in ref. 10). Nelson, J. B., J. Exp. Med., 96, 303 (1952).

    Article  Google Scholar 

  5. Braunsteiner, H., and Friend, C., J. Exp. Med., 100, 665 (1954).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Cheever, F. S., Daniels, J. B., Pappenheimer, A. M., and Bailey, O. T., J. Exp. Med., 90, 181 (1949).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Havens, jun., W. P., Proc. Soc. Exp. Biol., 58, 203 (1945).

    Article  Google Scholar 

  8. Pollard, M., and Starr, T. J., Fed. Proc., 18, 501 (1959).

    Google Scholar 

  9. Cabasso, V. J., Stebbins, M. R., Norton, T. W., and Cox, H. R., Proc. Soc. Exp. Biol. Med., 85, 239 (1954). Fieldsteel, A. H., and Emery, J. B., ibid., 86, 819 (1954). Emery, J. B., and York, C. J., Science, 127, 148 (1958).

    Article  CAS  PubMed  Google Scholar 

  10. Miyazaki, Y., Katsuta, H., Aoyama, Y., Kawai, K., and Takaoka, T., Japan. J. Exp. Med., 27, 381 (1957). Gompels, A. E. H., and Niven, J. S. F., J. Path. and Bact., 66, 567 (1953).

    CAS  Google Scholar 

  11. Starr, T. J., and Pollard, M., Proc. Soc. Exp. Biol. Med., 100, 97 (1959).

    Article  CAS  PubMed  Google Scholar 

  12. Pollard, M., and Bussell, R. H., Science, 126, 1245 (1957).

    Article  ADS  CAS  PubMed  Google Scholar 

  13. Larin, N. M., J. Hyg., 49, 410 (1951). Mansi, W., J. Comp. Pathol. Therap., 65, 291 (1955).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Symposium on the “Laboratory Propagation and Detection of the Agent of Hepatitis”, Nat. Acad. Sci. Nat. Research Council, Pub. No. 322 (1954).

  15. Gledhill, A. W., Dick, G. W. A., and Niven, J. S. F., Proc. Sixth Cong. Intern. Microbiol., Rome, 3, 219 (1953).

    Google Scholar 

  16. Dick, G. W. A., Niven, J. S. F., and Gledhill, A. W., Brit. J. Exp. Path., 37, 90 (1956).

    CAS  PubMed  PubMed Central  Google Scholar 

  17. Nelson, J. B., J. Exp. Med., 96, 293 (1952).

    Article  PubMed Central  Google Scholar 

  18. Bengtson, I. A., Pub. Health Rep., 59, 402 (1944).

    Article  Google Scholar 

  19. Lackey, M. D., Eichman, P. L., and Havens, jun., W. P., J. Infect. Dis., 93, 14 (1953).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. University of Texas Medical Branch, Department of Preventive Medicine and Public Health, Virus Research Laboratory, Galveston, Texas

    THEODORE J. STARR & MORRIS POLLARD

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  1. THEODORE J. STARR
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  2. MORRIS POLLARD
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STARR, T., POLLARD, M. Complement Fixation with Tissue Culture and Liver Antigens of Mouse Hepatitis. Nature 183, 1690–1691 (1959). https://doi.org/10.1038/1831690a0

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