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Purification of Neuraminidase from Vibrio cholerae

Nature volume 183, pages 1677–1678 (1959)Cite this article

Abstract

Blix, Gottschalk, and Klenk1 proposed the name ‘neuraminidase’ for the enzyme which splits the glycosidic linkage joining terminal (substituted or unsubstituted) neuraminic acid to residual oligo- or poly-saccharide. Kuhn and Brossmer2 and recently Gottschalk and Graham3 have isolated well-defined substrates by which the enzymatic action of neuraminidase could be studied. There exist many other substrates of high molecular weight and unknown structure; for example, mucoproteins from urine, saliva, serum, or stromata of erythrocytes. Neuraminidase is present in viruses of the myxo-group (influenza, fowl plague, Newcastle disease, mumps) and was found in filtrates of Vibrio cholerae 4 and Clostridium welchii 5.

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References

  1. Blix, F. G., Gottschalk, A., and Klenk, E., Nature, 179, 1088 (1957).

    Article  ADS  CAS  Google Scholar 

  2. Kuhn, R., and Brossmer, R., Chem. Ber., 89, 2471 (1956); Angewandte Chem., 70, 25 (1958).

    Article  CAS  Google Scholar 

  3. Gottschalk, A., and Graham, E. R. B., Z. Naturforsch., 13 b, 821 (1958).

    Article  Google Scholar 

  4. Burnet, F. M., and Stone, J. D., Austral. J. Exp. Biol., 25, 227 (1947).

    Article  CAS  Google Scholar 

  5. McCrea, J. F., Austral. J. Exp. Biol., 25, 127 (1947).

    Article  Google Scholar 

  6. Tamm, I., and Horsfall, F. L., J. Exp. Med., 95, 71 (1952).

    Article  CAS  Google Scholar 

  7. Böhm, P., Dauber, St., and Baumeister, L., Klin. Wochensch., 32, 289 (1954).

    Article  Google Scholar 

  8. Moore, St., and Stein, W. H., J. Biol. Chem., 211, 907 (1954).

    CAS  Google Scholar 

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Authors and Affiliations

  1. Max-Planck-Institut für Virusforschung, Tübingen

    GERHARD SCHRAMM & ELISABETH MOHR

Authors
  1. GERHARD SCHRAMM
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  2. ELISABETH MOHR
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SCHRAMM, G., MOHR, E. Purification of Neuraminidase from Vibrio cholerae . Nature 183, 1677–1678 (1959). https://doi.org/10.1038/1831677a0

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