Different Heterogeneities of Mouse Hæmoglobin according to Strains

Abstract

TWO different electrophoretic hæmoglobin patterns have been demonstrated by paper electrophoresis in inbred strains of mice, and these have been shown to be under genetic control^1,2. By means of moving-boundary electrophoresis, four different peaks have been observed in strains of genetically anæmic mice (ref. 3 and Cook, J. (personal communication) has observed three major peaks and two minor ones by chromatography on ‘Amberlite X64’). In studies on two different strains of mice by electrophoresis in gelosis, Van Bekkum, D. W., and Welling, W. (personal communication), have demonstrated in one of them the existence of a single hæmoglobin component, and in the other the existence of several components. This communication describes the different patterns obtained by starch gel electrophoresis of hæmoglobins from six inbred strains of mice.