Abstract
Two years ago, Witkin1 reported experiments indicating that protein synthesis was essential for the “fixation” of the mutagenic state induced by ultra-violet irradiation. More recently, Doudney and Haas2 have shown that at least two processes are involved in the production of bacterial mutations by ultra-violet irradiation; the first process results in fixation of the mutation into the genome, the second involves a removal of the mutagen produced by the radiation. We would like to report experiments that indicate that protein synthesis is involved in the actual utilization or degradation of the mutagen produced by ultra-violet irradiation.
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References
Witkin, E. M., Cold Spring Harbor Symposium Quant. Biol., 21, 123 (1956).
Doudney, C. O., and Haas, F. L., Proc. U.S. Nat. Acad. Sci., 44, 390 (1958).
Roberts, R., Abelson, P., Cowie, D., Bolton, E., and Britten, R., “Studies of Biosynthesis in Escherichia coli”, 607 (Carnegie Inst. of Wash. Pub., 1955).
Sharon, N., and Lipmann, F., Arch. Biochem. Biophys., 69, 219 (1957).
Brawerman, G., and Ycas, M., Arch. Biochem. Biophys., 68, 112 (1957).
Munier, R., and Cohen, G. N., Biochim. Biophys. Acta, 21, 592 (1956).
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SCHWARTZ, N., STRAUSS, B. Effect of Tryptophan Analogues on Reversion of a Tryptophan-requiring Strain of Escherichia coli . Nature 182, 888 (1958). https://doi.org/10.1038/182888a0
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DOI: https://doi.org/10.1038/182888a0
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