Abstract
MOST antibiotics are crystalloid molecules and are, for this reason, primarily circulated through the body by a vascular route. Concentrations of antibiotics in lymph and lymph nodes are often difficult to raise to significant levels. On the other hand, it is an established fact that macromolecules and colloidal particles have a particular affinity for the lymphatic system and can therefore attain high concentrations in lymph and lymph nodes.
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MÁLEK, P., HEROLD, M., HOFFMAN, J. et al. Lymphotrophic Antibiotics. Nature 181, 706–707 (1958). https://doi.org/10.1038/181706a0
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DOI: https://doi.org/10.1038/181706a0
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