Abstract
CHLORTETRACYCLINE is an inhibitor of some enzymatic reactions1–5. So far as the inhibition of hydrolases is concerned, reports in the literature are contradictory6–9. We demonstrated in previous work that pancreatic and mould α-amylase10,11 and pancreatic lipase are inhibited by aureomycin (Lederle). It was possible to prevent the inhibitive effect of this antibiotic substance by adding citrate, oxalate and the sodium salts of other organic acids. If, however, pure chlortetracycline was used inhibition did not occur. It was assumed that citrate prevented the inhibitive effect by removing calcium, which is present in the usual clinical Lederle preparation or in raw enzymatic preparations, from the system.
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ROKOS, J., BURGER, M. & PROCHÁZKA, P. Effect of Calcium Ions on the Inhibition of Hydrolases by Chlortetracycline. Nature 181, 1201 (1958). https://doi.org/10.1038/1811201a0
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DOI: https://doi.org/10.1038/1811201a0
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