Abstract
THE isolation of uranediol from the urine of pregnant mares has been described by Marker and his colleagues1 and by Klyne2; isolation has also been effected by Bauld and Heard3. Since the reported isolations of uranediol have been few, and since uranediol appears to be the first D-homosteroid of natural origin to be isolated4,5, we believe that it is of interest to record that we have isolated uranediol in small quantity from pregnant mares' urine collected throughout the second half of the term of pregnancy.
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References
Marker, R. E., et al., (a) J. Amer. Chem. Soc., 60, 210 (1938); (b) ibid., 60, 1061 (1938); (c) ibid., 60, 1561 (1938); (d) ibid., 61, 2719 (1939).
Klyne, W., Biochem. J., 43, 611 (1948).
Bauld, W. S., and Heard, R. D. H. (unpublished observations, 1940), cited in Pincus, G., and Thimann, K. V., “The Hormones”, 1, 618 (Academic Press, New York, 1948).
Klyne, W., Nature, 166, 559 (1950).
Klyne, W., and Shoppee, C. W., Chem. and Indust., 470 (1952).
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GLEN, W., BARBER, R. & GRANT, G. Isolation of Uranediol from the Urine of Pregnant Mares. Nature 180, 288 (1957). https://doi.org/10.1038/180288a0
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DOI: https://doi.org/10.1038/180288a0
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