Abstract
THE optical resolution of dl-3-methylpent-1-yn-3-ol was achieved for the first time by one of us1 some two years ago, and it seemed of interest to determine whether the narcotic activity of the optical antipodes differed, in spite of the contrary finding in the barbituric acid series. The criterion of narcosis was abolition of the righting reflex in female mice.
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References
Hickman and Kenyon, J. Chem. Soc., 2051 (1955).
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HICKMAN, J., MARSHALL, P. Narcotic Activity of Optical Enantiomorphs of Methylpentynol. Nature 180, 1053–1054 (1957). https://doi.org/10.1038/1801053b0
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DOI: https://doi.org/10.1038/1801053b0
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