Abstract
IT has widely been assumed that the antigen thought to constitute the capsule or ‘envelope’ which surrounds plague organisms in vivo 1 and which forms under suitable conditions in vitro 2 is essential for full virulence of P. pestis in mice. This antigen has been isolated by Baker et al. 3 and given the name Fraction 1 (F1). From their studies on the relative abilities of strains to produce F1 and toxin, Englesberg et al. 4 correlated high virulence for mice with ability to produce maximal amounts of F1 and toxin.
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References
Rowland, S., J. Hyg., 13, Plague Supplement III, 418 (1914).
Schütze, H., Brit. J. Exp. Path., 15, 200 (1934).
Baker, E. E., Sommer, H., Foster, L. E., Meyer, E., and Meyer, K. F., Proc. Soc. Exp. Biol., 64, 193 (1947).
Englesberg, E., Chen, T. H., Levy, S. B., Foster, L. E., and Meyer, K. F., Science, 119, 413 (1954).
Burrows, T. W., and Bacon, G. A., Brit. J. Exp. Path., 37, 286, 481 (1956).
Jackson, S., and Burrows, T. W., Brit. J. Exp. Path., 37, 570, 577 (1956).
Meyer, K. F., Proc. 4th Int. Congress Trop. Med., 264 (1948).
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BURROWS, T. Virulence of Pasteurella pestis . Nature 179, 1246–1247 (1957). https://doi.org/10.1038/1791246a0
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DOI: https://doi.org/10.1038/1791246a0
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