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Synthesis and Biological Activity of a New Potent Analogue of Oxytocin

Nature volume 178, pages 260–261 (1956)Cite this article

Abstract

USING the recently described method for the synthesis of oxytocin1, it was possible to prepare structural analogues of oxytocin by replacing the iso-leucyl group by valyl, leucyl or phenylalanyl groups. Of the series obtained, the valyl analogue of oxytocin (‘valyl-oxytocin’) was the most active and interesting substance. A description of its synthesis and some biological properties follow :

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Authors and Affiliations

  1. Laboratory of Organic and Pharmaceutical Chemistry, University, Geneva,

    R. A. BOISSONNAS, ST. GUTTMANN, P.-A. JAQUENOUD & J.-P. WALLER

  2. Department of Pharmaceutical Chemistry, Sandoz, Ltd., Basle

    R. A. BOISSONNAS, ST. GUTTMANN, P.-A. JAQUENOUD & J.-P. WALLER

  3. Department of Pharmacology, Sandoz, Ltd., Basle

    H. KONZETT & B. BERDE

Authors
  1. R. A. BOISSONNAS
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  2. ST. GUTTMANN
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  3. P.-A. JAQUENOUD
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  4. J.-P. WALLER
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  5. H. KONZETT
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  6. B. BERDE
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BOISSONNAS, R., GUTTMANN, S., JAQUENOUD, PA. et al. Synthesis and Biological Activity of a New Potent Analogue of Oxytocin. Nature 178, 260–261 (1956). https://doi.org/10.1038/178260a0

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