Abstract
IN their experiments with bacteriophages, Hershey and Chase1 have shown that only the nucleic acid component plays a part in the intracellular multiplication. There are also indications that in simple viruses containing ribonucleic acid the nucleic acid plays a dominant part in the infection. Thus, experiments with tobacco mosaic virus have shown that the protein can be changed chemically without affecting the activity and the genetic properties2; recently, it was even found3 that part of the protein can be removed from tobacco mosaic virus without destroying the activity.
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References
Hershey, A. D., and Chase, M., J. Gen. Physiol., 36, 39 (1952).
Schramm, G., and Müller, H., Hoppe Seylers Z. physiol. Chem., 266, 43 (1940); 274, 267 (1942). Miller, G. L., and Stanley, W. M., J. Biol. Chem., 141, 905 (1941); 146, 331 (1942). Harris, J. I., and Knight, C. A., J. Biol. Chem., 214, 215 (1955).
Schramm, G., Schumacher, G., and Zillig, W., Nature, 175, 549 (1955).
Fraenkel-Conrat, H., and Williams, R. C., Proc. U.S. Nat. Acad. Sci., 41, 690 (1955).
Lippincott, J. A., and Commoner, B., Biochim. Biophys. Acta, 19, 198 (1956).
Hart, R. G., Nature, 177, 130 (1956).
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GIERER, A., SCHRAMM, G. Infectivity of Ribonucleic Acid from Tobacco Mosaic Virus. Nature 177, 702–703 (1956). https://doi.org/10.1038/177702a0
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DOI: https://doi.org/10.1038/177702a0
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