Abstract
RECENTLY, Gillman et al. 1 and Simpson2 reported that trypan blue injected subcutaneously into rats at weekly or bi-weekly intervals induced tumour (reticulum cell sarcoma) of the liver. Trypan blue is a sulphonated dis-azo dye and somewhat resembles in chemical structure dimethylaminoazobenzene, which is a potent carcinogen for the liver of rats.
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References
Gillman, J., Gillman, T., and Gilbert, C., S. Afr. J. Med. Sci., 14, 21 (1949).
Simpson, C. L., Brit. J. Exp. Path., 33, 524 (1952).
Miller, J. A., “Advances in Cancer Research”, 1, 389 (Academic Press, N.Y., 1953).
Miller, E. C., and Miller, J. A., Cancer Research, 7, 468 (1947).
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IWASE, S., FUJITA, K. Inhibiting Effect of Trypan Blue on the Experimental Production of Liver Cancer. Nature 175, 552 (1955). https://doi.org/10.1038/175552a0
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DOI: https://doi.org/10.1038/175552a0
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