Abstract
DURING the past ten months, I have been feeding rats on thioacetamide with the object of studying chronic intoxication induced by that compound. 1 gm. of thioacetamide was dissolved in 60 ml. absolute alcohol, thoroughly mixed with 3,125 gm. of M.R.C. powdered rat cubes, and the alcohol evaporated off. One hundred and fifty rats received unlimited amounts of this mixture; fifty had the control diet consisting of powdered cubes mixed with absolute alcohol in the same ratio as in the experimental mixture. Groups of animals were killed at regular intervals from each batch for a careful study of the liver pathology.
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GUPTA, D. Production of Cancer of the Bile Ducts with Thioacetamide. Nature 175, 257 (1955). https://doi.org/10.1038/175257a0
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DOI: https://doi.org/10.1038/175257a0
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