Abstract
A NUMBER of clinical observations have established that recent immunization with diphtheria or whooping cough vaccines renders children more susceptible to poliomyelitis infection (see Hill and Knowelden1 for references). A similar effect has been demonstrated in mice infected with the virus of mouse encephalomyelitis (GDVII strain) in experiments which are being reported fully elsewhere. During the course of the work, however, it was observed that the injection of vaccines which had been stored for several months no longer made the mice more susceptible to virus infection, but instead exerted a protective effect. It is felt that these findings, if confirmed, might have an important bearing on both clinical and biological problems.
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References
Hill, A. B., and Knowelden, J., Brit. Med. J., ii, 1 (1950).
Finney, D. J., “Probit Analysis” (Cambridge, 1947).
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McLAREN, A. Protective Effect of Aged Vaccines on a Neurotropic Virus Infection in Mice. Nature 172, 38 (1953). https://doi.org/10.1038/172038a0
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DOI: https://doi.org/10.1038/172038a0
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