Abstract
PURE ‘Parathion’ is not at present considered to be an inhibitor of cholinesterase in vitro1–3. It is probable that those who first reported4–6 to the contrary were using samples contaminated with one or more of the following: O-S-diethyl p-nitrophenyl thiophosphate, diethyl S-p-nitrophenyl thiophosphate and diethyl p-nitrophenyl phosphate (‘Paraoxon’), all of which possess anticholinesterase activity in vitro2.
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References
Diggle, W. M., and Gage, J. C., Biochem. J., 49, 491 (1951).
Aldridge, W. N., and Barnes, J. M., Nature, 169, 345 (1952).
Stegwee, D., Biochim. Biophys. Acta, 8, 187 (1952).
Aldridge, W. N., Biochem. J., 46, 451 (1950).
DuBois, Kenneth P., Doull, John, Salerno, Paul R., and Coon, Julius M., J. Pharmacol., 95, 79 (1949).
Grob, David, Johns Hopkins Hosp. Bull., 87, 95 (1950).
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PAYTON, J. ‘Parathion’ and Ultra-violet Light. Nature 171, 355–356 (1953). https://doi.org/10.1038/171355a0
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DOI: https://doi.org/10.1038/171355a0
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