Abstract
MANY methods have already been described for the selective degradation of peptides from the carboxyl end1. However, the several chemical steps involved in those procedures do not allow their utilization on a micro-scale. Linstead, Shephard and Weedon2 have recently published a study on the decarboxylation of α-N-acylamino-acids in alcoholic media by anodic oxidation into alkoxyalkylamides (acylaminoethers), with a 74–91 per cent yield.
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Linstead, R. P., Shephard, B. R., and Weedon, B. C. L., J. Chem. Soc., 2854 (1951).
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BOISSONNAS, R. Stepwise Degradation of Polypeptides from the Carboxyl End. Nature 171, 304 (1953). https://doi.org/10.1038/171304a0
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DOI: https://doi.org/10.1038/171304a0
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