Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Autografting

Splenic rupture in a patient with plasma cell myeloma following G-CSF/GM-CSF administration for stem cell transplantation and review of the literature

Bone Marrow Transplantation volume 40, pages 361–364 (2007)Cite this article

Abstract

Recipients of granulocyte-colony stimulating factor/granulocyte macrophage-colony stimulating factor are not only individuals with underlying disorders, but also healthy donors undergoing peripheral blood progenitor cell (PBPC) mobilization. In addition to the known adverse effects associated with G-CSF, complications such as splenic rupture have also been reported. A review of the English literature, with addition of a patient with plasma cell myeloma, reveals that splenic rupture occurs not only in patients with underlying disease, but also in healthy PBPC donors. Although the cause of splenic rupture does not appear to be associated with any specific condition, physicians should be alerted to the possibility of this potentially fatal complication in individuals receiving G-CSF therapy.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Anderlini P, Przepiorka D, Champlin R, Korbling M . Biologic and clinical effects of granulocyte colony-stimulating factor in normal individuals. Blood 1996; 88: 2819–2825.

    CAS  Google Scholar 

  2. Zimmer BM, Berdel WE, Ludwig WD, Notter M, Reufi B, Thiel E . Fatal spleen rupture during induction chemotherapy with rh GM-CSF priming for acute monocytic leukemia. Clinical case report and in vitro studies. Leuk Res 1993; 17: 277–283.

    Article  CAS  Google Scholar 

  3. Becker PS, Wagle M, Matous S, Swanson RS, Pihan G, Lowry PA et al. Spontaneous splenic rupture following administration of granulocyte colony-stimulating factor (G-CSF): occurrence in an allogeneic donor of peripheral blood stem cells. Biol Blood Marrow Transplant 1997; 3: 45–49 [Erratum in Biol Blood Marrow Transplant 1997; 3: 108].

    CAS  PubMed  Google Scholar 

  4. Kasper C, Jones L, Fujita Y, Morgenstern GR, Scarffe JH, Chang J . Splenic rupture in a patient with acute myeloid leukemia undergoing peripheral blood stem cell transplantation. Ann Hematol 1999; 78: 91–92.

    Article  CAS  Google Scholar 

  5. Falzetti F, Aversa F, Minelli O, Tabilio A . Spontaneous rupture of spleen during peripheral blood stem-cell mobilisation in a healthy donor. Lancet 1999; 353: 555.

    CAS  PubMed  Google Scholar 

  6. Pitini V, Ciccolo A, Arrigo C, Aloi G, Micali C, La Torre F . Spontaneous rupture of spleen during peripheral blood stem cell mobilization in a patient with breast cancer. Haematologica 2000; 85: 559–560.

    CAS  PubMed  Google Scholar 

  7. O'Malley DP, Whalen M, Banks PM . Spontaneous splenic rupture with fatal outcome following G-CSF administration for myelodysplastic syndrome. Am J Hematol 2003; 73: 294–295.

    Article  Google Scholar 

  8. Oran B, Wright DG, Seldin DC, McAneny D, Skinner M, Sanchorawala V . Spontaneous rupture of the spleen in AL amyloidosis. Am J Hematol 2003; 74: 131–135.

    Article  CAS  Google Scholar 

  9. Balaguer H, Galmes A, Ventayol G, Bargay J, Besalduch J . Splenic rupture after granulocyte-colony-stimulating factor mobilization in a peripheral blood progenitor cell donor. Transfusion 2004; 44: 1260–1261.

    Article  Google Scholar 

  10. Dincer AP, Gottschall J, Margolis DA . Splenic rupture in a parental donor undergoing peripheral blood progenitor cell mobilization. J Pediatr Hematol Oncol 2004; 26: 761–763.

    Article  Google Scholar 

  11. Arshad M, Seiter K, Bilaniuk J, Qureshi A, Asawari P, Ramaswamy G et al. Side effects related to cancer treatment: CASE 2. Splenic rupture following pegfilgrastim. J Clin Oncol 2005; 23: 8533–8534.

    Article  Google Scholar 

  12. Nuamah NM, Goker H, Kilic YA, Dagmoura H, Cakmak A . Spontaneous splenic rupture in a healthy allogeneic donor of peripheral-blood stem cell following the administration of granulocyte colony-stimulating factor (g-csf). A case report and review of the literature. Haematologica 2006; 91: 9–11.

    Google Scholar 

  13. Kuendgen A, Fenk R, Bruns I, Dommach M, Schutte A, Engers R et al. Splenic rupture following administration of pegfilgrastim in a patient with multiple myeloma undergoing autologous peripheral blood stem cell transplantation. Bone Marrow Transplant 2006; 38: 69–70.

    Article  CAS  Google Scholar 

  14. Platzbecker U, Prange-Krex G, Bornhauser M, Koch R, Soucek S, Aikele P et al. Spleen enlargement in healthy donors during G-CSF mobilization of PBPCs. Transfusion 2001; 41: 184–189.

    Article  CAS  Google Scholar 

  15. Stroncek D, Shawker T, Follmann D, Leitman SF . G-CSF-induced spleen size changes in peripheral blood progenitor cell donors. Transfusion 2003; 43: 609–613.

    Article  CAS  Google Scholar 

  16. Stroncek DF, Dittmar K, Shawker T, Heatherman A, Leitman SF . Transient spleen enlargement in peripheral blood progenitor cell donors given G-CSF. J Transl Med 2004; 21: 25.

    Article  Google Scholar 

  17. Meguid AA, Ivascu FA, Bair HA, Kerr H, Bendick PJ, McFall RK et al. Management of blunt splenic injury in patients with concurrent infectious mononucleosis. Am Surg 2004; 70: 801–804.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    R Veerappan, M Morrison & D Variakojis

  2. Department of Medicine, Hematology/Oncology Division, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    S Williams

Authors
  1. R Veerappan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M Morrison
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S Williams
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. D Variakojis
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to D Variakojis.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Veerappan, R., Morrison, M., Williams, S. et al. Splenic rupture in a patient with plasma cell myeloma following G-CSF/GM-CSF administration for stem cell transplantation and review of the literature. Bone Marrow Transplant 40, 361–364 (2007). https://doi.org/10.1038/sj.bmt.1705736

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1705736

Keywords

This article is cited by

Search

Advanced search

Quick links