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Post-Transplant Events

A prospective randomized study of clinical and economic consequences of using G-CSF following autologous peripheral blood progenitor cell (PBPC) transplantation in children

Bone Marrow Transplantation volume 34, pages 1077–1081 (2004)Cite this article

Summary:

This prospective and randomized study was conducted to evaluate clinical and economic consequences of using granulocyte colony-stimulating factor (G-CSF) following autologous peripheral blood progenitor cell (PBPC) transplantation in children. Between January 1999 and December 2003, 117 patients underwent autologous PBPCT: 51 patients received G-CSF following PBPCT, while 66 patients did not receive G-CSF. Median time to absolute neutrophil count >0.5 × 109/l was 10 days in the treatment group and 11 days in the control group (P<0.009). The median time to platelets >20 × 109/l was 12 days in both groups (P=NS). The median time to platelets >50 × 109/l was 15 days in the G-CSF group and 14 days in the control group (P<0.005). In patients who received <5 × 106/kg CD34+ cells, the median time to platelets >20 × 109/l and >50 × 109/l was similar with or without G-CSF (12 and 15 days, respectively). Platelet transfusion requirements were lower in the control group (2 vs 3 U in G-CSF group). There was a trend towards higher total costs with G-CSF: 8146.82 euros and 7873.34 euros with and without G-CSF, respectively (P=0.1). Our data suggest that there is no indication of the standard application of G-CSF in children following PBPC transplantation. The only possible indication is the group of patients with a lower yield of CD34+ cells.

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Acknowledgements

This work was partially supported by ‘Fundación Oncohematología Pediátrica’.

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  1. Pediatric Oncohematology Department, Hematopoietic Transplantation Unit, Hospital Niño Jesús, Madrid, Spain

    M González-Vicent, L Madero, J Sevilla, M Ramirez & M A Díaz

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  1. M González-Vicent
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  2. L Madero
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Correspondence to M A Díaz.

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González-Vicent, M., Madero, L., Sevilla, J. et al. A prospective randomized study of clinical and economic consequences of using G-CSF following autologous peripheral blood progenitor cell (PBPC) transplantation in children. Bone Marrow Transplant 34, 1077–1081 (2004). https://doi.org/10.1038/sj.bmt.1704699

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