Summary:
We retrospectively reviewed the results of serial pulmonary function tests (PFT) after allogeneic bone marrow transplantation (BMT) performed in 80 children at a single institution over a 16-year period. We looked for associations linking PFT results to graft-versus-host disease (GVHD), conditioning regimen (total body irradiation (TBI) vs busulphan), and cytomegalovirus immune status. The median follow-up after BMT was 4 years. At 2 years after BMT, significant declines were found in forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1), as compared to baseline. Both FEV1 and the FEV1/FVC ratio showed significantly greater reductions in the group conditioned with busulphan (n=22) than in the group conditioned with TBI (n=49) and were significantly lower in the patients with (n=16) than without (n=64) chronic GVHD. Busulphan may be associated with greater long-term lung toxicity than TBI. The relevance of this finding to selection of conditioning regimens for BMT should be examined in the light of the overall pattern of side effects. Chronic GVHD was associated with airway obstruction.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
We are sorry, but there is no personal subscription option available for your country.
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Griese M, Rampf U, Hofmann D et al. Pulmonary complications after bone marrow transplantation in children: twenty-four years of experience in a single pediatric center. Pediatr Pulmonol 2000; 30: 393–401.
Cerveri I, Zoia MC, Fulgoni P et al. Late pulmonary sequelae after childhood bone marrow transplantation. Thorax 1999; 54: 131–135.
Kaplan EB, Wodell RA, Wilmott RW et al. Late effects of bone marrow transplantation on pulmonary function in children. Bone Marrow Transplant 1994; 14: 613–621.
Fanfulla F, Locatelli F, Zoia MC et al. Pulmonary complications and respiratory function changes after bone marrow transplantation in children. Eur Respir J 1997; 10: 2301–2306.
Leneveu H, Brémont F, Rubie H et al. Respiratory function in children undergoing bone marrow transplantation. Pediatr Pulmonol 1999; 28: 31–38.
Quigley PM, Yeager AM, Loughlin GM . The effects of bone marrow transplantation on pulmonary function in children. Pediatr Pulmonol 1994; 18: 361–367.
Depledge M, Barrett A, Powles R . Lung function after bone marrow grafting. Int J Radiat Oncol Biol Phys 1983; 9: 141–151.
Rodriguez-Roisin R, Granena A, Agusti AGN et al. Lung function in allogeneic bone marrow transplantation recipients. Eur Respir J 1989; 2: 359–365.
Sutedja T, Apperley JF, Hughes JMB et al. Pulmonary function bone marrow transplantation for chronic myeloid leukaemia. Thorax 1988; 43: 163–169.
Santos GW, Tutschka PJ, Brookmeyer R et al. Marrow transplantation for acute nonlymphocytic leukemia after treatment with busulfan and cyclophosphamide. N Engl J Med 1983; 309: 1347–1353.
Cooper JAD, White DA, Matthay RA . Drug-induced pulmonary disease. Part 1: Cytotoxic drugs. Am Rev Respir Dis 1986; 133: 321–340.
Vergnon JM, Boucheron S, Riffat J et al. Interstitial pneumopathies caused by busulfan. Histologic, developmental and bronchoalveolar lavage analysis of 3 cases. Rev Med Interne 1988; 9: 377–383.
Burns WA, McFarland W, Matthews MJ . Busulfan-induced pulmonary disease. Report of a case and review of the literature. Am Rev Respir Dis 1970; 101: 408–413.
Barrett A . Relationship of irradiation to pulmonary complications. Exp Hematol 1984; 12: 6–7.
Weshler Z, Breuer R, Or R et al. Interstitial pneumonitis after total body irradiation: effects of total lung shielding. Br J Haematol 1990; 74: 61–64.
Deeg HJ, Sullivan KM, Buckner CD et al. Marrow transplantation for acute nonlymphoblastic leukemia in first remission: toxicity and long-term follow-up of patients conditioned with single dose or fractionated total body irradiation. Bone Marrow Transplant 1986; 1: 151–157.
Socie G, Devergie A, Girinsky T et al. Influence of the fractionation of total body irradiation on complications and relapse rate for chronic myelogenous leukemia. The Groupe d'Etude des greffes de moelle osseuse (GEGMO). Int J Radiat Oncol Biol Phys 1991; 20: 397–404.
Keane TJ, Van Dyk J, Rider W . Idiopathic interstitial pneumonia following bone marrow transplantation: the relationship with total body irradiation. Int J Radiat Oncol Biol Phys 1981; 7: 1365–1370.
Ringden O, Remberger M, Ruutu T et al. Increased risk of graft-versus-host disease, obstructive bronchiolitis and alopecia with busulfan versus total body irradiation: long-term results of a randomized trial in allogeneic bone marrow recipients with leukemia. Blood 1999; 7: 2196–2201.
De Marco R, Dassio DA, Vittone P . A retrospective study of ocular side effects in children undergoing bone marrow transplantation. Eur J Ophthalmol 1996; 6: 436–439.
Leiper AD, Stanhope R, Lau T et al. The effect of total body irradiation and bone marrow transplantation during childhood and adolescence on growth and endocrine function. Br J Haematol 1987; 67: 419–426.
Socié G, Curtis RE, Deeg HJ et al. New malignant diseases after allogeneic marrow transplantation for childhood acute leukaemia. J Clin Oncol 2000; 18: 348–357.
Prince DS, Wingard JR, Saral R et al. Longitudinal changes in pulmonary function following bone marrow transplantation. Chest 1989; 96: 301–306.
Clark JG, Crawford SW, Madtes DK et al. Obstructive lung disease after allogeneic marrow transplantation. Ann Intern Med 1989; 111: 368–376.
Clark JG, Schwartz DA, Flournoy N et al. Risk factors for airflow obstruction in recipients of bone marrow transplants. Ann Intern Med 1987; 107: 648–656.
Link H, Reinhard U, Blaurock M et al. Lung function changes after allogenic bone marrow transplantation. Thorax 1986; 41: 508–512.
Wyatt SE, Nunn P, Hows JM et al. Airways obstruction associated with graft versus host disease after bone marrow transplantation. Thorax 1984; 39: 887–894.
Curtis DJ, Smale A, Thien F et al. Chronic airflow obstruction in long-term survivors of allogeneic bone marrow transplantation. Bone Marrow Transplant 1995; 16: 169–173.
Epler GR . Bronchiolitis obliterans and airways obstruction associated with graft-versus-host disease. Clin Chest Med 1988; 9: 551–556.
McDonald GB, Sullivan KM, Schuffler MD et al. Esophageal abnormalities in chronic graft-versus-host disease in humans. Gastroenterology 1981; 80: 914–921.
Schubert MM, Sullivan KM, Morton TH . Oral manifestations of chronic graft-v-host disease. Arch Intern Med 1984; 144: 1591–1595.
Izutsu KT, Sullivan KM, Schubert MM . Disordered salivary immunoglobulin secretion and sodium transport in human chronic graft-versus-host disease. Transplantation 1983; 35 (Suppl 5): 441–446.
Bleyzac N, Souillet G, Magron P et al. Improved clinical outcome of paediatric bone marrow recipients using a test dose and Baysian pharmacokinetic individualization of busulfan dosage regimens. Bone Marrow Transplant 2001; 28: 743–751.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Bruno, B., Souillet, G., Bertrand, Y. et al. Effects of allogeneic bone marrow transplantation on pulmonary function in 80 children in a single paediatric centre. Bone Marrow Transplant 34, 143–147 (2004). https://doi.org/10.1038/sj.bmt.1704549
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1704549
Keywords
This article is cited by
-
Preclinical validation and treatment of volumetric modulated arc therapy based total bone marrow irradiation in Halcyon™ ring gantry linear accelerator
Radiation Oncology (2022)
-
Cardiorespiratory fitness and physical performance after childhood hematopoietic stem cell transplantation: a systematic review and meta-analysis
Bone Marrow Transplantation (2021)
-
Decline of forced expiratory volume in 1 s after allogeneic hematopoietic cell transplantation is a good indicator for pulmonary damage and is associated with busulfan use
International Journal of Hematology (2019)
-
Effect of dose rate on pulmonary toxicity in patients with hematolymphoid malignancies undergoing total body irradiation
Radiation Oncology (2018)
-
Pulmonary function after hematopoietic stem cell transplantation is significantly better in pediatric recipients following reduced toxicity compared with myeloablative conditioning
Bone Marrow Transplantation (2016)