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Progenitor Cell Mobilization

Good and poor CD34+ cells mobilization in acute leukemia: analysis of factors affecting the yield of progenitor cells

Bone Marrow Transplantation volume 33, pages 1083–1087 (2004)Cite this article

Summary:

The factors possibly affecting the collection of peripheral blood stem cells (PBSC) were evaluated in 104 de novo acute leukemia patients (66 myeloid and 38 lymphoblastic leukemias) in first cytological complete remission (CR); all patients achieved CR after first-line induction chemotherapy. The acute myeloid leukemia patients (AML) were given consolidation–mobilization chemotherapy with cytarabine, and daunoblastin or mitoxantrone or idarubicin; the acute lymphoblastic leukemia patients (ALL) were given consolidation–mobilization chemotherapy with cytarabine and etoposide. In all patients, the collection of PBSC was performed during recovery after giving consolidation chemotherapy and granulocyte colony-stimulating factor (G-CSF). Two main groups were considered according to the CD34+ cells × 106/kg b.w. collected, that is, poor mobilizers (PM), with a collection of <2 × 106/kg and good mobilizers, with a collection of >2 × 106/kg. Of 104 patients, 27 (25.9%) were PM; 20/27 had AML and 7/27 had ALL. At multivariate analysis, a lower CD34+ cells count premobilization chemotherapy (CD34 steady state), the presence of FUO (fever of unknown origin) or infection, and a lower number of CD34+ cells on the first day of collection correlated with poor mobilization. These results may enable early recognition of patients who may have poor mobilization, and aid selection of patients for different mobilization regimens.

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Acknowledgements

This work was supported by Ministero dell'Istruzione dell'Università e della Ricerca (MIUR); we thank Ms MVC Pragnell, BA, for language assistance in the preparation of the manuscript.

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  1. Department DIMIMP, Hematology Section, University of Bari, Italy

    D Pastore, G Specchia, A Mestice, A Liso, A Pannunzio, P Carluccio, C Buquicchio, G Greco, L Ciuffreda, G Pietrantuono & V Liso

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Correspondence to G Specchia.

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Pastore, D., Specchia, G., Mestice, A. et al. Good and poor CD34+ cells mobilization in acute leukemia: analysis of factors affecting the yield of progenitor cells. Bone Marrow Transplant 33, 1083–1087 (2004). https://doi.org/10.1038/sj.bmt.1704437

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