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Post-Transplant Complications

Mesial temporal sclerosis – a late complication in four allogeneic pediatric recipients with persistent seizures after an acute episode of cyclosporine-A neurotoxicity

Bone Marrow Transplantation volume 31, pages 919–922 (2003)Cite this article

Summary:

Mesial temporal sclerosis (MTS) is a common finding in patients with intractable temporal lobe epilepsy (TLE). In this report, we retrospectively reviewed the neuroimaging results of four children who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT), and who developed recurrent, partial, intractable seizures following a first event caused by cyclosporine-A (CSA) neurotoxicity. Neuroradiologic findings of MTS were demonstrated in all these patients. We suggest that MTS may be a consequence of CSA neurotoxicity, which induces repeated seizures, associated with other predisposing conditions, as well as being a consequence of the underlying disease and its treatment, and of severe graft-versus-host disease (GvHD).

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References

  1. Reece DE, Frei-Lahr DA, Shephers JD et al. Neurologic complications in allogeneic bone marrow transplant patients receiving cyclosporin. Bone Marrow Transplant 1991; 8: 393–401.

    CAS  PubMed  Google Scholar 

  2. Gleeson JG, DuPlessis AJ, Barnes PD, Riviello JJ . Cyclosporin A acute encephalopathy and seizure syndrome in childhood: clinical features and risk of seizure recurrence. J Child Neurol 1998; 13: 336–344.

    Article  CAS  PubMed  Google Scholar 

  3. Faraci M, Lanino E, Dini G et al. Severe neurologic complications after hematopoietic stem cell transplantation in children. Neurology 2002; 59: 1895.

    Article  CAS  PubMed  Google Scholar 

  4. Kuzniecky RI, Jackson GD . Temporal Lobe Epilepsy. In: Kuzniecky RI, Jackson GD (eds) Magnetic Resonance in Epilepsy. Raven Press: New York, 1995, pp 107–182.

    Google Scholar 

  5. Provenzale JM, Graham ML . Reversible leukoencephalopathy associated with graft-versus-host disease: MR findings. Am J Neuroradiol 1996; 17: 1290–1294.

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Padovan CS, Bise K, Hahn J et al. Angiitis of the central nervous system after allogeneic bone marrow transplantation? Stroke 1999; 30: 1651–1656.

    Article  CAS  PubMed  Google Scholar 

  7. Liu Z, Mikati M, Holmes GL . Mesial temporal sclerosis: pathogenesis and significance. Pediatr Neurol 1995; 12: 5–16.

    Article  CAS  PubMed  Google Scholar 

  8. Serrano-Castro P, Sanchez-Alvarez JC, Garcia-Gomez T . Mesial temporal sclerosis (I): histological data, physiopathological hypothesis and etiological factors. Rev Neurol 1997; 25: 584–589.

    CAS  PubMed  Google Scholar 

  9. Cukiert A, Andrioli MS, Caner-Cukiert AR . Unilateral mesial temporal atrophy after a systemic insult as a possible etiology of refractory temporal lobe epilepsy. Case report. Arq Neuropsiquiatr 1997; 55: 646–649.

    Article  CAS  PubMed  Google Scholar 

  10. Sanchez-Alvarez JC, Pastor-Pons E, Garcia-Gomez T et al. Diagnosis of mesial temporal sclerosis with magnetic resonance imaging. Rev Neurol 2000; 31: 739–741.

    Google Scholar 

  11. Wainwright MS, Martin PL, Morse RP et al. Human herpes 6 limbic encephalitis after stem cell transplantation. Ann Neurol 2001; 50: 612–619.

    Article  CAS  PubMed  Google Scholar 

  12. Wong M, Yamada KA . Cyclosporine induces epileptiform activity in an in vitro seizure model. Epilepsia 2000; 41: 271–276.

    Article  CAS  PubMed  Google Scholar 

  13. Shbarou RM, Chao NJ, Morgenlander JC . Cyclosporin A-related cerebral vasculopathy. Bone Marrow Transplant 2000; 26: 801–804.

    Article  CAS  PubMed  Google Scholar 

  14. Mathern GW, Pretorius JK, Babb TL . Influence of the type of initial precipitating injury and at what age it occurs on course and outcome in patients with temporal lobe seizures. J Neurosurg 1995; 82: 220–227.

    Article  CAS  PubMed  Google Scholar 

  15. Gilliam F, Faught E, Martin R et al. Predictive value of MRI -identified mesial temporal sclerosis for surgical outcome in temporal lobe epilepsy: an intent-to-treat analysis. Epilepsia 2000; 41: 963–966.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

This work was supported in part by “Ricerca Finalizzata Ministeriale 2002”, by “Compagnia San Paolo”, and by “Carige Foundation”.

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Authors and Affiliations

  1. Department of Hematology and Oncology, Bone Marrow Transplant Unit, G. Gaslini Children's Research Institute, Genova, Italy

    M Faraci, E Lanino, S Dallorso, G Morreale, B Cappelli & G Dini

  2. Department of Neurology, G. Gaslini Children's Research Institute, Genova, Italy

    R Gaggero

  3. Department of Epidemiology and Biostatistics Section, G. Gaslini Children's Research Institute, Genova, Italy

    R Haupt

  4. Department of Neuroradiology, G. Gaslini Children's Research Institute, Genova, Italy

    M P Fondelli

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  1. M Faraci
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  2. E Lanino
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  5. B Cappelli
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  7. G Dini
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  9. M P Fondelli
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Faraci, M., Lanino, E., Dallorso, S. et al. Mesial temporal sclerosis – a late complication in four allogeneic pediatric recipients with persistent seizures after an acute episode of cyclosporine-A neurotoxicity. Bone Marrow Transplant 31, 919–922 (2003). https://doi.org/10.1038/sj.bmt.1704023

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