Abstract
COHN1 has shown that carotene and vitamin A are concentrated in fraction III-O of plasma, which is a lipoprotein. It has been known for some time2 that vitamin A can occur in water-soluble form in the urine of human beings in certain pathological conditions. In such cases protein is invariably present in the urine. It does not follow, however, that urine which contains protein can take up vitamin A when added to it. Adequate explanation of this phenomenon has not been forthcoming. The function of vitamin A in the visual cycle has been very elegantly demonstrated by Wald3. Recently, Morton4 has shown that retinene, which is an important factor in the visual cycle, is vitamin A aldehyde, and he has also shown5 how it can be prepared in the laboratory. It was therefore considered that attempts should be made to prepare a water-soluble compound of vitamin A with plasma protein and study its properties. The present preliminary communication summarizes the results obtained in this Institute.
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References
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RAJAGOPAL, K., DATTA, P. Reaction of Vitamin A Aldehyde with Plasma Albumin. Nature 170, 370–371 (1952). https://doi.org/10.1038/170370a0
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DOI: https://doi.org/10.1038/170370a0
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