Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Meeting Report
  • Published:

New concepts about graft-versus-host and graft-versus-leukaemia-reactions. A summary of the 5th International Symposium held in Munich, 21 and 22 March 2002

Abstract

The Fifth International Symposium on Graft-versus-Host and Graft-versus-Leukemia Reactions was held on 21 and 22 March 2002 in the University Hospital (Klinikum Grosshadern) of the University of Munich. As in previous years, it was dedicated to the encounter of scientists and clinicians involved in hematopoietic cell transplantation. This year's symposium focused on the characterization of stem cells potentially expanding the use of hematopoietic stem cells and on gene therapy. The immunology section dealt with mechanisms of tolerance, and the characterization of minor histocompatibility antigens presented by major histocompatibility molecules. Further important topics were cytokines and dendritic cells. In 1½ days of intense work, the invited speakers, chairmen, authors and an active audience experienced an exciting exchange of ideas and collaboration. Again, new impulses were given for basic research and clinical transplantation. The authors would like to express their deep appreciation and thanks to all participants of this symposium.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

References

  1. Rossig C, Bollard CM, Nuchtern JG et al. Epstein–Barr virus-specific human T lymphocytes expressing antitumor chimeric T cell receptors: potential for improved immunotherapy Blood 2002 99: 2009 2016

    Article  CAS  Google Scholar 

  2. Horwitz EM, Prockop DJ, Gordon PL et al. Clinical responses to bone marrow transplantation in children with severe osteogenesis imperfecta Blood 2001 97: 1227 1231

    Article  CAS  Google Scholar 

  3. Li Z, Düllmann J, Schiedlmeier B et al. Murine leukemia induced by retroviral gene marking Science 2002 296: 497

    Article  CAS  Google Scholar 

  4. Oostendorp RA, Harvey KN, Kusadasi N et al. Stromal cell lines from mouse aorto-gonads-mesonephros subregions are potent supporters of hematopoietic stem cell activity Blood 2002 99: 1183 1189

    Article  CAS  Google Scholar 

  5. Feuring-Buske M, Frankel AE, Alexander RL et al. A diphtheria toxin-interleukin 3 fusion protein is cytotoxic to primitive acute myeloid leukemia progenitors but spares normal progenitors Cancer Res 2002 62: 1730 1736

    CAS  PubMed  Google Scholar 

  6. Feuring-Buske, Hogge DE . Hoechst 33342 efflux identifies a subpopulation of cytogenetically normal CD34+CD38 progenitor cells from patients with acute myeloid leukemia Blood 2002 97: 3882 3889

    Article  Google Scholar 

  7. Buske C, Feuring-Buske M, Abramovich C et al. Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells Blood 2002 100: 862 868

    Article  CAS  Google Scholar 

  8. Smith ES, Mandokhot A, Evans EE et al. Lethality based selection of recombinant genes in mammalian cells: application to identifying tumour antigens Nat Med 2001 7: 967 972

    Article  CAS  Google Scholar 

  9. Bachar-Lustig E, Li HW, Gur H et al. Induction of donor-type chimerism and transplantation tolerance across major histocompatibility barriers in sublethally irradiated mice by Sca-1 (+) Lin (−) bone marrow progenitor cells: synergism with non-alloreactive (host x donor) F (1) T cells Blood 1999 94: 3212 3221

    CAS  Google Scholar 

  10. Gur H, Krauthgamer R, Berrebi A et al. Tolerance induction by megadose hematopoietic progenitor cells: expansion of veto cells by short term expansion of purified human CD34 cells Blood 2002 99: 4174 4181

    Article  CAS  Google Scholar 

  11. Reich-Zeliger S, Zhao Y, Krauthgamer R et al. Anti-third party CD8 CTLs as potent veto cells: coexpression of CD8 and FasL is a prerequisite Immunity 2000 13: 507 515

    Article  CAS  Google Scholar 

  12. Kurokawa T, Oelke M, Mackensen A . Induction and clonal expansion of tumor specific cytotoxic T lymphocytes from renal cell carcinoma patients after stimulation with autologous dendritic cells loaded with tumor cells Int J Cancer 2001 91: 749 756

    Article  CAS  Google Scholar 

  13. Dickinson AM, Cavet J, Cullup H et al. GVHD risk assessment in hematopoietic stem cell transplantation: role of cytokine gene polymorphisms and an in vitro human skin explant model Hum Immunol 2001 62: 1266 1276

    Article  CAS  Google Scholar 

  14. Teshima T, Ordemann R, Reddy P et al. Acute graft-versus host disease does not require alloantigen expression on host epithelium Nat Med 2002 8: 575 581

    Article  CAS  Google Scholar 

  15. Wendtner CM, Kofler DM, Theiss HD et al. Efficient gene transfer of CD40 ligand into primary B-CLL cells using recombinant adeno-associated virus (rAAV) vectors Blood 2002 100: 1655 1661

    CAS  PubMed  Google Scholar 

  16. Mavroudis DA, Dermine S, Molldrem J et al. Specific depletion of alloreactive T cells in graft-versus-host and graft-versus-leukaemia reactions Br J Haematol 1998 101: 565 570

    Article  CAS  Google Scholar 

  17. Cavazzana-Calvo M, Andre-Schmutz I, Hacein-Bey-Abina S et al. Improving immune reconstitution while preventing graft-versus-host disease in allogeneic stem cell transplantation Semin Hematol 2002 39: 32 40

    Article  CAS  Google Scholar 

  18. Stanislawski T, Voss RH, Lotz C et al. Circumventing tolerance to a human MDM2-derived tumor antigen by TCR gene transfer Nat Immunol 2001 2: 962 970

    Article  CAS  Google Scholar 

  19. Steidl U, Kronenwett R, Rohr UP et al. Gene expression profiling identifies significant differences between the molecular phenotypes of bone marrow-derived and circulating human CD34+ hematopoietic stem cells Blood 2002 99: 2037 2044

    Article  CAS  Google Scholar 

  20. Dolstra H, Fredrix H, Maas F et al. A human minor histocompatibility antigen specific for B cell acute lymphoblastic leukemia J Exp Med 1999 189: 301 308

    Article  CAS  Google Scholar 

  21. Clark RE, Dodi IA, Hill SC et al. Direct evidence that leukemic cells present HLA-associated immunogenic peptides derived from the BCR-ABL b3a2 fusion protein Blood 2001 98: 2887 2893

    Article  CAS  Google Scholar 

  22. Norbury LC, Clark RE, Christmas SE . b3a2 BCR-ABL fusion peptides as targets for cytotoxic T cells in chronic myeloid leukaemia Br J Haematol 2000 109: 616 621

    Article  CAS  Google Scholar 

  23. Dickinson AM, Wang XN, Sviland L et al. In situ disection of the graft-versus-host activities of cytotoxic T cells specific for minor histocompatibility antigens Nat Med 2002 8: 410 414

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to R Munker.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Munker, R., Günther, W. & Kolb, H. New concepts about graft-versus-host and graft-versus-leukaemia-reactions. A summary of the 5th International Symposium held in Munich, 21 and 22 March 2002. Bone Marrow Transplant 30, 549–556 (2002). https://doi.org/10.1038/sj.bmt.1703690

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1703690

Keywords

Search

Quick links