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Complications Post Transplant

Secondary thyroid carcinoma after allogeneic bone marrow transplantation during childhood

Bone Marrow Transplantation volume 28, pages 1125–1128 (2001)Cite this article

Abstract

The aim of this study was to evaluate the incidence and risk factors related to secondary thyroid carcinoma (STC) in patients who have undergone allogeneic BMT during childhood. Data related to the primary hematological disorder and BMT procedure were obtained from the records of 113 patients (42 F; 71 M) who underwent BMT before the age of 18 (median 10.0 years; range 1.7–18.0) and survived more than 3 years after transplant with a median follow-up of 10.1 years (range 3.0–19.0). Sixteen received cranial radiation (CRT) during first-line treatment. Pre-transplant conditioning included TBI in 85 patients, TAI in two, while 26 children did not receive irradiation. The standardized incidence ratio of STC after BMT was significantly higher (P < 0.001) than that of the general population. STC was found in eight patients, 3.1 to 15.7 years after transplant. All received TBI and three also CRT. The Cox's regression analysis, although not statistically significant due to the small study population, showed an increased risk in those who had received a cumulative radiation dose higher than 10 Gy and in those who developed chronic GVHD. Careful follow-up of thyroid status including annual ultrasound examination is recommended for early detection of tumor.

Bone Marrow Transplantation (2001) 28, 1125–1128.

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References

  1. Deeg HJ, Socié G . Malignancies after hematopoietic stem cell transplantation: many questions, some answers Blood 1998 91: 1833–1844

    CAS  PubMed  Google Scholar 

  2. Witherspoon RP, Fisher LD, Schoch G et al. Secondary cancer after bone marrow transplantation for leukemia or aplastic anemia New Engl J Med 1989 321: 784–789

    Article  CAS  PubMed  Google Scholar 

  3. Socié G, Henry-Amar M, Cosset JM et al. Increased incidence of solid malignant tumors after bone marrow transplantation for severe aplastic anemia Blood 1991 78: 277–279

    PubMed  Google Scholar 

  4. Bhatia S, Ramsay NK, Steinbuch M et al. Malignant neoplasms following bone marrow transplantation Blood 1996 87: 3633–3639

    CAS  PubMed  Google Scholar 

  5. Lowsky R, Lipton J, Fyles G et al. Secondary malignancies after bone marrow transplantation in adults J Clin Oncol 1994 12: 2187–2192

    Article  CAS  PubMed  Google Scholar 

  6. Deeg HJ, Socié G, Henry-Amar M et al. Malignancies after marrow transplantation for aplastic anemia and Fanconi anemia: a joint Seattle and Paris analysis of results in 700 patients Blood 1996 87: 386–392

    CAS  PubMed  Google Scholar 

  7. Curtis ER, Rowlings PA, Deeg HJ et al. Solid cancers after bone marrow transplantation New Engl J Med 1997 336: 897–904

    Article  CAS  PubMed  Google Scholar 

  8. Kolb HJ, Socié G, Duell T et al. Malignant neoplasms in long-term survivors of bone marrow transplantation Ann Intern Med 1999 131: 738–744

    Article  CAS  PubMed  Google Scholar 

  9. Sociè G, Curtis RE, Sobocinski KA et al. New malignant diseases after allogeneic marrow transplantation for childhood acute leukemia J Clin Oncol 2000 18: 348–357

    Article  PubMed  Google Scholar 

  10. Uderzo C, van Lint MT, Rovelli A et al. Papillary thyroid carcinoma after total body irradiation Arch Dis Child 1994 71: 256–258

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Rovelli A, Cohen A, Uderzo C et al. Follicular cell carcinoma of the thyroid in a child after bone marrow transplantation for acute lymphoblastic leukemia Acta Haematol 1997 97: 225–227

    Article  CAS  PubMed  Google Scholar 

  12. Epilog Plus Statistics Package for Epidemiology and Clinical Trials Pasadena, CA: Epicenter Software 1988

  13. Parkin DM, Whelan SL, Ferlag J et al. Cancer Incidence in Five Continents Vol. VII: IARC Scientific Publications: Lyon 1997 p 143

    Google Scholar 

  14. SPSS 9 Statistical Package SPSS Inc: Chicago, IL 1999

  15. Viswanathan K, Gierlowski TC, Schneider AB . Childhood thyroid cancer Arch Pediatr Adolesc Med 1994 148: 260–265

    Article  CAS  PubMed  Google Scholar 

  16. Ron E, Lubin JH, Shore RE et al. Thyroid cancer after exposure to external radiation: a pooled analysis of seven studies Radiat Res 1995 141: 259–277

    Article  CAS  PubMed  Google Scholar 

  17. Bessho F, Ohta K, Akanuma A, Sakata KI . Dosimetry of radiation scattered to thyroid gland from prophylactic cranial irradiation for childhood leukemia Pediatr Haematol Oncol 1994 11: 47–53

    Article  CAS  Google Scholar 

  18. Beatty O III, Hudson MM, Greenwald C et al. Subsequent malignancies in children and adolescents after treatment for Hodgkin's disease J Clin Oncol 1995 13: 603–609

    Article  Google Scholar 

  19. Sankila R, Garwicz S, Olsen JH et al. Risk of subsequent malignant neoplasms among 1641 Hodgkin's disease patients diagnosed in childhood and adolescence: a population-based cohort study in the five Nordic countries J Clin Oncol 1997 14: 1442–1446

    Article  Google Scholar 

  20. Neglia JP, Meadows AT, Robison LL et al. Second neoplasms after acute lymphoblastic leukemia in childhood New Engl J Med 1991 325: 1330–1336

    Article  CAS  PubMed  Google Scholar 

  21. Black P, Straaten A, Gutjahr P . Secondary thyroid carcinoma after treatment for childhood cancer Med Pediatr Oncol 1998 31: 91–95

    Article  CAS  PubMed  Google Scholar 

  22. Katsanis E, Shapiro RS, Robison LL et al. Thyroid dysfunction following bone marrow transplantation: long-term follow-up of 80 pediatric patients Bone Marrow Transplant 1990 5: 335–340

    CAS  PubMed  Google Scholar 

  23. Borgstrom B, Bolme P . Thyroid function in children after allogeneic bone marrow transplantation Bone Marrow Transplant 1994 13: 59–64

    CAS  PubMed  Google Scholar 

Download references

Acknowledgements

We thank the nonprofit ‘Associazione CRESCI’ and ‘Comitato ML Verga’ for their help in the accomplishment of this study and Miss J Upton for linguistic consultancy and secretarial assistance.

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Authors and Affiliations

  1. Department of Pediatrics, San Paolo Hospital, Savona, Italy

    A Cohen, A Gaiero & R Mulas

  2. Department of Pediatrics, Bone Marrow Transplantation Unit, University of Milano-Bicocca, San Gerardo Hospital, Monza, Italy

    A Rovelli, A Balduzzi, P Corti & C Uderzo

  3. Department of Hematology II, Bone Marrow Transplantation Unit, San Martino Hospital, Genoa, Italy

    MT van Lint & A Bacigalupo

  4. Department of Environmental Epidemiology and Biostatistics, Unit of Analytical Epidemiology, National Cancer Research Institute, Genoa, Italy

    F Merlo

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  1. A Cohen
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Cohen, A., Rovelli, A., van Lint, M. et al. Secondary thyroid carcinoma after allogeneic bone marrow transplantation during childhood. Bone Marrow Transplant 28, 1125–1128 (2001). https://doi.org/10.1038/sj.bmt.1703290

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