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Graft-Versus-Host Disease

Increased hepatocyte growth factor in serum in acute graft-versus-host disease

Bone Marrow Transplantation volume 28, pages 197–200 (2001)Cite this article

Abstract

Hepatocyte growth factor (HGF) was reported to be effective in preventing acute graft-versus-host disease (GVHD) in a murine model. We examined serum HGF concentrations in 38 patients receiving allogeneic bone marrow transplants, and investigated the relationship of serum HGF concentrations to severity of acute GVHD. More HGF was present in sera from patients with than without acute GVHD. Serum HGF correlated significantly with grade of acute GVHD. Furthermore, serum HGF correlated with serum concentrations of C-reactive protein, γ-glutamyltranspeptidase (GTP), and aspartate aminotransferase (AST). Serum concentrations of HGF in transplanted patients without GVHD were consistently low, while those in patients with acute GVHD increased with exacerbation. We conclude that HGF was produced during induction of the GVH reaction, and probably increased as a physiological response. Bone Marrow Transplantation (2001) 28, 197–200.

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References

  1. Nakamura T, Nawa K, Ichihara A . Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats Biochem Biophys Res Commun 1984 122: 1450–1459

    Article  CAS  Google Scholar 

  2. Nakamura T, Nishizawa T, Hagiya M et al. Molecular cloning and expression of human hepatocyte growth factor Nature 1989 342: 440–443

    Article  CAS  Google Scholar 

  3. Kawaida K, Matsumoto K, Shimazu H, Nakamura T . Hepatocyte growth factor prevents acute renal failure and accelerates renal regeneration in mice Proc Natl Acad Sci USA 1994 91: 4357–4361

    Article  CAS  Google Scholar 

  4. Ohmichi H, Matsumoto K, Nakamura T . In vivo mitogenic action of HGF on lung epithelial cells: pulmotrophic role in lung regeneration Am J Physiol 1996 14: L1031–L1039

    Google Scholar 

  5. Kato Y, Yu D, Lukish JR, Schwarts MZ . Influence of luminar hepatocyte growth factor on small intestine mucosa in vivo J Surg Res 1997 71: 49–53

    Article  CAS  Google Scholar 

  6. Bottaro DP, Rubin JS, Faletto DL et al. Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product Science 1991 251: 802–804

    Article  CAS  Google Scholar 

  7. Bardelli A, Longati P, Albero D et al. HGF receptor associates with anti-apoptotic protein BAG-1 and prevents cell death EMBO J 1996 15: 6205–6212

    Article  CAS  Google Scholar 

  8. Fan S, Ma YX, Wang JA et al. The cytokine hepatocyte growth factor/scatter factor inhibits apoptosis and enhances DNA repair by a common mechanism involving signaling through phosphatidyl inositol 3′ kinase Oncogene 2000 19: 2212–2223

    Article  CAS  Google Scholar 

  9. Kmiecik TE, Rosen KE, Van de Woude GF . Hepatocyte growth factor is a synergistic factor for the growth of hematopoietic progenitor cells Blood 1992 80: 2454–2457

    CAS  PubMed  Google Scholar 

  10. Ratajczak MZ, Marlicz W, Ratajczak J et al. Effect of hepatocyte growth factor on early human haemopoietic cell development Br J Haematol 1997 99: 228–236

    Article  CAS  Google Scholar 

  11. Matsuda Y, Matsumoto K, Ichida T, Nakamura T . Hepatocyte growth factor prevents liver cirrhosis caused by dimethylnitrosamine in rats J Biochem 1999 118: 643–649

    Article  Google Scholar 

  12. Ueki T, Kaneda Y, Tsutsui H et al. Hepatocyte growth factor gene therapy of liver cirrhosis in rats Nat Med 1999 5: 226–230

    Article  CAS  Google Scholar 

  13. Kataoka Y, Iwasaki T, Kuroiwa T et al. Therapeutic effects in mice of hepatocyte growth factor (HGF) gene therapy of graft-vs-host disease (GVHD)-induced enteropathy and hematopoietic dysfunction Blood 1999 94 (Suppl. 1): 392a

    Google Scholar 

  14. Kuroiwa T, Kakishita E, Hamano T et al. Hepatocyte growth factor gene therapy ameliorates acute graft-versus-host disease and promotes donor cell engraftment J Clin Invest 2001 (in press)

  15. Glucksberg H, Storb R, Fefer A et al. Clinical manifestations of graft-versus-host disease in human recipients of marrow from HLA-matched sibling donors Transplantation 1974 18: 295–304

    Article  CAS  Google Scholar 

  16. Matsumoto K, Nakamura T . Emerging multipotent aspects of hepatocyte growth factor J Biochem 1996 119: 591–600

    Article  CAS  Google Scholar 

  17. Shiota G, Okano J, Kawasaki H et al. Serum hepatocyte growth factor levels in liver diseases: clinical implications Hepatology 1995 21: 106–112

    Article  CAS  Google Scholar 

  18. Hino M, Inaba M, Goto H et al. Hepatocyte growth factor levels in bone marrow plasma of patients with leukaemia and its gene expression in leukaemic blast cells Br J Cancer 1996 73: 119–123

    Article  CAS  Google Scholar 

  19. Taniguchi T, Toi M, Inada K et al. Serum concentrations of hepatocyte growth factor in breast cancer patients Clin Cancer Res 1995 1: 1031–1034

    CAS  PubMed  Google Scholar 

  20. Taniguchi T, Kitamura M, Arai K et al. Increase in the circulating level of hepatocyte growth factor in gastric cancer patients Br J Cancer 1997 75: 673–677

    Article  CAS  Google Scholar 

  21. Sakon M, Kita Y, Yoshida T et al. Plasma hepatocyte growth factor levels are increased in systemic inflammatory response syndrome Surg Today 1996 26: 236–241

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors are grateful to Mrs Aki Nomura for invaluable assistance with the ELISA for HGF.

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  1. Second Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan

    T Okamoto, H Takatsuka, Y Fujimori, H Wada, T Iwasaki & E Kakishita

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  1. T Okamoto
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  2. H Takatsuka
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Okamoto, T., Takatsuka, H., Fujimori, Y. et al. Increased hepatocyte growth factor in serum in acute graft-versus-host disease. Bone Marrow Transplant 28, 197–200 (2001). https://doi.org/10.1038/sj.bmt.1703095

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