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Preoperative high-dose chemotherapy with peripheral blood stem cell support as a primary management of locally advanced breast cancer

Bone Marrow Transplantation volume 27, pages 345–346 (2001)Cite this article

Abstract

Locally advanced breast cancer (LABC) has a poor prognosis with a high risk of local recurrence and distant metastasis. Preoperative combined chemotherapy with or without granulocyte colony-stimulating factor (G-CSF) support does not improve the long-term survival rate. In our report, two patients with LABC received preoperative high-dose chemotherapy with peripheral blood stem cell support (HDC/PBSCs). Prior to high-dose chemotherapy with peripheral blood stem cell support, they both received induction chemotherapy of cyclophosphamide, epirubicin and 5-fluorouracil (FEC) for two cycles which resulted in a partial response. PBSC mobilization and collection were carried out following the second cycle of induction chemotherapy followed by G-CSF. High-dose cyclophosphamide (2500 mg/m2), carboplatin (600 mg/m2) and etoposide (600 mg/m2) were administered with PBSC support. A radical mastectomy was performed followed by adjuvant chemotherapy with FEC regimen for four cycles, followed by local irradiation, and endocrine therapy with tamoxifen. Both patients achieved a remarkable response in the primary lesion after HDC/PBSCs and tolerated the whole treatment well. Preoperative HDC/PBSCs as a new strategy in the treatment of LABC seems practical but it needs to be studied more deeply. Bone Marrow Transplantation (2001) 27, 345–346.

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References

  1. Booser DJ, Hortobagyi GN . Treatment of locally advanced breast cancer Semin Oncol 1992 19: 278–285

    CAS  PubMed  Google Scholar 

  2. Valero V . Future direction of neoadjuvant therapy for breast cancer Semin Oncol 1998 25: (Suppl. 3) 36–41

    CAS  PubMed  Google Scholar 

  3. Rubens RD, Sexton S, Tong D et al. Combined chemotherapy and radiotherapy for locally advanced breast cancer Eur J Cancer 1980 16: 351–356

    Article  CAS  Google Scholar 

  4. Mamounas EP . Overview of national surgical adjuvant breast project neoadjuvant chemotherapy studies Semin Oncol 1998 25: (Suppl. 3) 31–35

    CAS  PubMed  Google Scholar 

  5. Fisher B, Brown A, Mamounas E et al. Effect of preoperative chemotherapy on local-regional disease in women with operable breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-18 J Clin Oncol 1997 15: 2483–2493

    Article  CAS  Google Scholar 

  6. Stadtmauer EA, O'Neill A, Goldstein LJ et al. Conventional-dose chemotherapy compared with high-dose chemotherapy plus autologous hematopoietic stem-cell transplantation for metastatic breast cancer. Philadelphia Bone Marrow Transplant Group New Engl J Med 2000 342: 1069–1076

    Article  CAS  Google Scholar 

  7. Antman KH . Critique of the high-dose chemotherapy studies in breast cancer: a positive look at the data J Clin Oncol 1999 17: (Suppl.) 30–34

    CAS  PubMed  Google Scholar 

  8. Hortobagyi GN . High-dose chemotherapy for primary breast cancer: facts versus anecdotes J Clin Oncol 1999 17: (Suppl.) 25–29

    Article  CAS  Google Scholar 

  9. Hortobagyi GN, Buzdar AU, Theriault RL . Randomized trial of high-dose chemotherapy and blood cell autografts for high-risk primary breast carcinoma J Natl Cancer Inst 2000 92: 225–233.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Medical Oncology, Department of Surgery, Jiangsu Cancer Research Institute, Nanjing, People's Republic of China

    X Wang, J Tang, J Wu, J Feng, L Pang, A Dai & X Zheng

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  1. X Wang
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  2. J Tang
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  3. J Wu
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  4. J Feng
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  5. L Pang
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  6. A Dai
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  7. X Zheng
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Wang, X., Tang, J., Wu, J. et al. Preoperative high-dose chemotherapy with peripheral blood stem cell support as a primary management of locally advanced breast cancer. Bone Marrow Transplant 27, 345–346 (2001). https://doi.org/10.1038/sj.bmt.1702787

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  • DOI: https://doi.org/10.1038/sj.bmt.1702787

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