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Cryofibrinogenemia and skin necrosis in a patient with diffuse large cell lymphoma after high-dose chemotherapy and autologous stem cell transplantation

Bone Marrow Transplantation volume 26, pages 1343–1345 (2000)Cite this article

Abstract

A 34-year-old woman with diffuse mediastinal B cell large cell lymphoma presented 60 days after high-dose chemotherapy and autologous stem cell transplantation, and post-transplant immunotherapy with interleukin-2, with skin necrosis in the ears and extremities. Extensive work-up revealed the presence of cryofibrinogenemia and associated thrombotic vasculopathy. The patient was successfully treated with corticosteroids and therapeutic plasma exchange. However, she had recurrence of large cell lymphoma a few weeks later and died of progressive disease. Cryfibrinogenemia and skin necrosis may have occurred secondary to the imminent relapse, or as a rare complication of high-dose chemotherapy or treatment with interleukin-2. Bone Marrow Transplantation (2000) 26, 1343–1345.

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Authors and Affiliations

  1. The Department of Blood and Marrow Transplantation, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    A Shimoni, M Körbling & R Champlin

  2. Department of Blood and Marrow Transplantation, Section of Transplant Immunology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Box 24, Houston, 77030, TX, USA

    J Molldrem

Authors
  1. A Shimoni
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  2. M Körbling
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  3. R Champlin
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  4. J Molldrem
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Shimoni, A., Körbling, M., Champlin, R. et al. Cryofibrinogenemia and skin necrosis in a patient with diffuse large cell lymphoma after high-dose chemotherapy and autologous stem cell transplantation. Bone Marrow Transplant 26, 1343–1345 (2000). https://doi.org/10.1038/sj.bmt.1702678

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  • DOI: https://doi.org/10.1038/sj.bmt.1702678

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