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Juvenile myelomonocytic leukemia relapsing after allogeneic bone marrow transplantation successfully treated with interferon-alpha

Bone Marrow Transplantation volume 26, pages 681–683 (2000)Cite this article

Abstract

We report a 5-year-old boy with juvenile myelomonocytic leukemia (JMML) which relapsed after an allogeneic bone marrow transplant who was successfully treated with interferon-α (IFN-α). One year after starting the therapy, he remains clinically well and in complete remission while continuing treatment with IFN-α and bestatin. Although the precise mechanism by which remission was induced is uncertain, a GVL effect combined with a direct antileukemia effect of IFN-α may be responsible. Further assessment of the role of IFN-α in relapsed JMLL patients is warranted. Bone Marrow Transplantation (2000) 26, 681–683.

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Authors and Affiliations

  1. Department of Developmental Medicine (Pediatrics), Osaka University Graduate School of Medicine, Suita, Osaka, Japan

    H Ohta, M Kawai, A Sawada, S Tokimasa, H Fujisaki, Y Matsuda, Y Osugi, S Okada & J Hara

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  1. H Ohta
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  2. M Kawai
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  3. A Sawada
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  4. S Tokimasa
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  6. Y Matsuda
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  7. Y Osugi
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  8. S Okada
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  9. J Hara
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Ohta, H., Kawai, M., Sawada, A. et al. Juvenile myelomonocytic leukemia relapsing after allogeneic bone marrow transplantation successfully treated with interferon-alpha. Bone Marrow Transplant 26, 681–683 (2000). https://doi.org/10.1038/sj.bmt.1702584

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  • DOI: https://doi.org/10.1038/sj.bmt.1702584

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